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AKOS037652256

Catalog No. T72073Cas No. 2171065-77-1

AKOS037652256 can be used as a TRPML modulator for the treatment of diseases associated with TRPML activity such as lysosomal accumulation disorders, muscular dystrophy, common age-related neurodegenerative diseases, oxidative stress or reactive oxygen species (ROS)-related diseases and ageing.

AKOS037652256

AKOS037652256

Purity: 98.81%
Catalog No. T72073Cas No. 2171065-77-1
AKOS037652256 can be used as a TRPML modulator for the treatment of diseases associated with TRPML activity such as lysosomal accumulation disorders, muscular dystrophy, common age-related neurodegenerative diseases, oxidative stress or reactive oxygen species (ROS)-related diseases and ageing.
Pack SizePriceAvailabilityQuantity
1 mg$195In Stock
5 mg$440In Stock
10 mg$648In Stock
25 mg$987In Stock
50 mg$1,390In Stock
100 mg$1,870In Stock
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Purity:98.81%
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Product Introduction

Bioactivity
Description
AKOS037652256 can be used as a TRPML modulator for the treatment of diseases associated with TRPML activity such as lysosomal accumulation disorders, muscular dystrophy, common age-related neurodegenerative diseases, oxidative stress or reactive oxygen species (ROS)-related diseases and ageing.
Targets&IC50
TRPML:< = 2 µM(AC50), TRPML1:< = 2 µM(AC50)
In vitro
AKOS037652256 (Compound 8) (0.1-3 μM) was sufficient to induce TFEB-nuclear translocation (nuclear to cytosol ratio increased in a dose-dependent manner.[2]
Chemical Properties
Molecular Weight553.07
FormulaC24H26ClFN4O4S2
Cas No.2171065-77-1
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 5.53 mg/mL (10 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8081 mL9.0404 mL18.0809 mL90.4045 mL
5 mM0.3616 mL1.8081 mL3.6162 mL18.0809 mL
10 mM0.1808 mL0.9040 mL1.8081 mL9.0404 mL

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