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AKOS037652256 can be used as a TRPML modulator for the treatment of diseases associated with TRPML activity such as lysosomal accumulation disorders, muscular dystrophy, common age-related neurodegenerative diseases, oxidative stress or reactive oxygen species (ROS)-related diseases and ageing.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | In Stock | |
5 mg | $440 | In Stock | |
10 mg | $648 | In Stock | |
25 mg | $987 | In Stock | |
50 mg | $1,390 | In Stock | |
100 mg | $1,870 | In Stock |
Description | AKOS037652256 can be used as a TRPML modulator for the treatment of diseases associated with TRPML activity such as lysosomal accumulation disorders, muscular dystrophy, common age-related neurodegenerative diseases, oxidative stress or reactive oxygen species (ROS)-related diseases and ageing. |
Targets&IC50 | TRPML:< = 2 µM(AC50), TRPML1:< = 2 µM(AC50) |
In vitro | AKOS037652256 (Compound 8) (0.1-3 μM) was sufficient to induce TFEB-nuclear translocation (nuclear to cytosol ratio increased in a dose-dependent manner.[2] |
Molecular Weight | 553.07 |
Formula | C24H26ClFN4O4S2 |
Cas No. | 2171065-77-1 |
Storage | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 5.53 mg/mL (10 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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