CEACAM6 Protein, Human, Recombinant (His), Biotinylated

Catalog No. TMPY-05460

CEACAM6 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.6 kDa and the accession number is P40199.

CEACAM6 Protein, Human, Recombinant (His), Biotinylated

Catalog No. TMPY-05460

CEACAM6 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.6 kDa and the accession number is P40199.

Pack Size	Price	Availability	Quantity
20 μg	$306	7-10 days
100 μg	$726	7-10 days

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Product Information

Biological Activity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	CEACAM6 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.6 kDa and the accession number is P40199.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	P40199
Synonyms	NCA,CEAL,CEA,CD66c,carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
Construction	A DNA sequence encoding the human CEACAM6 (NP_002474.3) (Met1-Gly320) with a C-terminal polyhistidine tag was expressed. The purified protein was biotinylated in vitro. Predicted N terminal: Lys 35
Protein Purity	> 95 % as determined by SDS-PAGE.
Molecular Weight	32.6 kDa (predicted)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. It s a glycosylphosphatidylinositol-linked immunoglobulin superfamily member that is overexpressed in a variety of human cancers, including colon, breast and lung and is associated with tumourigenesis, tumour cell adhesion, invasion and metastasis. CEACAM6 is a unique mediator of migration and invasion of drug resistant oestrogen-deprived breast cancer cells, and this protein could be an important biomarker of metastasis. CEACAM6 is expressed by granulocytes and their progenitors. It is also expressed by epithelia of various organs and is upregulated in pancreatic and colon adenocarcinomas, as well as hyperplastic polyps. Resistance to adhesion-related apoptosis in tumor cells is conferred in the condition of CEACAM6 overexpression.