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CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (aa 65-265, hFc)

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CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (aa 65-265, hFc)

Catalog No. TMPK-01004

CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (aa 65-265, hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 50.9 kDa and the accession number is Q5QGZ9-2.

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Pack Size	Price	Availability
100 μg	$534	7-10 days
500 μg	$2,140	7-10 days
1 mg	$3,570	7-10 days

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Biological Description

Biological Information	Immobilized Human CLEC12A, hFc Tag at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Biotinylated Anti-CLEC12A Antibody, hFc Tag with the EC50 of 20.2ng/ml determined by ELISA.
Description	CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (aa 65-265, hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 50.9 kDa and the accession number is Q5QGZ9-2.
Species	Human
Expression System	HEK293 Cells
Tag	N-hFc
Accession Number	Q5QGZ9-2
Synonyms	DCAL2,HECL,DCAL-2,DLEC,CLECSF11,CLEC12A,CD371,MICL,CLL-1,CLECSF7,CLL1,CD303,PRO34150
Construction	His65-Ala265
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight	50.9 kDa (predicted). Due to glycosylation, the protein migrates to 68-73 kDa based on Tris-Bis PAGE result.
Endotoxin	< 1 EU/μg by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML.