Shopping Cart

Remove All

Your shopping cart is currently empty

HER3/ERBB3 Protein, Human, Recombinant (hFc), Biotinylated

Resource Download

HER3/ERBB3 Protein, Human, Recombinant (hFc), Biotinylated

Catalog No. TMPY-05753

HER3/ERBB3 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95.4 kDa and the accession number is P21860-1.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability	Quantity
20 μg	$306	7-10 days
100 μg	$726	7-10 days

Bulk & Custom

Add to Cart

Questions

Biological Description

Biological Information	Testing in progress
Description	HER3/ERBB3 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95.4 kDa and the accession number is P21860-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	P21860-1
Synonyms	HER3,p180-ErbB3,MDA-BF-1,erbB3-S,p85-sErbB3,erb-b2 receptor tyrosine kinase 3,c-erbB3,LCCS2,p45-sErbB3,EEBB3,c-erbB-3,ErbB-3
Construction	The extracellular domain (Met1-Thr643) of Human ErbB3 (NP_001973.2) precursor was expressed with the C-terminal fused Fc region of Human IgG1. The purified protein was biotinylated in vitro.
Protein Purity	> 90 % as determined by SDS-PAGE
Molecular Weight	95.4 kDa (predicted)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy