1. Measured by its binding ability in a functional ELISA. 2. Immobilized Rhesus ERBB3 at 10 μg/mL (100 μL/well) can bind Human Fc-NRG1 (isoform Beta1) . The EC50 of Human Fc-NRG1 (isoform Beta1) is 0.51-1.19 μg/mL.

HER3/ERBB3 Protein, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 69.5 kDa and the accession number is XP_001113953.2.

Rhesus

HEK293 Cells

erb-b2 receptor tyrosine kinase 3

A DNA sequence encoding the rhesus ERBB3 (XP_001113953.2) (Met1-Thr643) was expressed with six amino acids (LEVLFQ) at the C-terminus. Predicted N terminal: Ser 20

≥ 90 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.

A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy