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(±)16-HETE

Catalog No. T35465Cas No. 128914-46-5

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 μM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity.

(±)16-HETE
Other Forms of (±)16-HETE:
9(S)-HETET37411107656-13-3
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9(R)-HETET37410107656-14-4
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(±)18-HETET35467133268-58-3
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8(R)-HETET37155105500-09-2
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5(R)-HETET3764861641-47-2
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16(R)-HETET35847183509-22-0
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(±)9-HETET3655879495-85-5
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(±)11-HETET3546273804-65-6
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8(S)-HETET3715898462-03-4
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19(R)-HETET36216115461-39-7
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17(S)-HETET35849183509-25-3
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17(R)-HETET37708183509-24-2
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12(R)-HETET3614582337-46-0
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(±)5-HETET3660473307-52-5
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19(S)-HETET35850115461-40-0
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11(R)-HETET3749073347-43-0
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16(S)-HETET35848183509-23-1
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(±)16-HETE

Catalog No. T35465Cas No. 128914-46-5
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 μM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity.
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25 μg$36535 days
50 μg$69535 days
100 μg$1,31035 days
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Product Introduction

Bioactivity
Description
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 μM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity.
Chemical Properties
Molecular Weight320.473
FormulaC20H32O3
Cas No.128914-46-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMF: Miscible
DMSO: Miscible
Ethanol: Miscible
PBS (pH 7.2): 0.8 mg/mL
0.1 M Na2CO3: 2 mg/mL

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Keywords

(±)16HETE(±)16 HETE16-HETE
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