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19(S)-HETE

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Catalog No. T35850Cas No. 115461-40-0

19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively. Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels. 19(S)-HETE stimulates both renal sodium-potassium ATPase and volume absorption in the rabbit proximal straight tubule.

19(S)-HETE

19(S)-HETE

😃Good
Catalog No. T35850Cas No. 115461-40-0
19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively. Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels. 19(S)-HETE stimulates both renal sodium-potassium ATPase and volume absorption in the rabbit proximal straight tubule.
Pack SizePriceAvailabilityQuantity
25 μg$365 35 days
50 μg$695 35 days
100 μg$1,310 35 days
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Product Introduction

Bioactivity
Description
19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively. Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels. 19(S)-HETE stimulates both renal sodium-potassium ATPase and volume absorption in the rabbit proximal straight tubule.
Chemical Properties
Molecular Weight320.473
FormulaC20H32O3
Cas No.115461-40-0
Relative Density.0.984 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
PBS (pH 7.2): 0.5 mg/mL (1.56 mM), Sonication is recommended.
DMSO: 20 mg/mL (62.41 mM), Sonication is recommended.
Ethanol: 50 mg/mL (156.02 mM), Sonication is recommended.
DMF: 20 mg/mL (62.41 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/DMSO/DMF/Ethanol
1mg5mg10mg50mg
1 mM3.1204 mL15.6019 mL31.2039 mL156.0194 mL
DMSO/DMF/Ethanol
1mg5mg10mg50mg
5 mM0.6241 mL3.1204 mL6.2408 mL31.2039 mL
10 mM0.3120 mL1.5602 mL3.1204 mL15.6019 mL
20 mM0.1560 mL0.7801 mL1.5602 mL7.8010 mL
50 mM0.0624 mL0.3120 mL0.6241 mL3.1204 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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