Shopping Cart
- Remove All
Your shopping cart is currently empty
(R)-(-)-α-Methylhistamine dihydrobromide
😃Good
Catalog No. T12630Cas No. 868698-49-1
(R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective H3 histamine receptor agonist with a dissociation constant (Kd) of 50.3 nM.
(R)-(-)-α-Methylhistamine dihydrobromide
😃Good
Catalog No. T12630Cas No. 868698-49-1
(R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective H3 histamine receptor agonist with a dissociation constant (Kd) of 50.3 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $1,880 | 35 days |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "(R)-(-)-α-Methylhistamine dihydrobromide"
Famotidine
MK-208
T162776824-35-6
Famotidine (MK-208) is a propanimidamide and histamine H2-receptor antagonist with antacid activity. As a competitive inhibitor of histamine H2-receptors on the basolateral membrane of parietal cells, famotidine reduces basal and nocturnal gastric acid secretion, thereby decreasing gastric volume, acidity, and the amount of gastric acid released in response to various stimuli.
- $50
Size
QTY
Sodium butanoate
Sodium Butyrate, Butanoic acid sodium salt
T1393156-54-7
Sodium butanoate (Sodium Butyrate) is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs).
- $33
Size
QTY
Meclizine dihydrochloride
NSC28728, Meclozine dihydrochloride, Meclizine 2HCl
T11101104-22-9
Meclizine dihydrochloride (NSC28728) is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.
- $50
Size
QTY
Alginic acid
Snow acid algin G, Sazzio, Protanal LF, Norgine, Kelacid
T205979005-32-7
Alginic acid (Snow acid algin G) is a natural polysaccharide extracted from brown seaweeds with anti-anaphylactic and anti-inflammatory activities. Alginic acid inhibits histamine release and can be used in the food industry.
- $29
Size
QTY
Lidocaine
Xylocaine, Lignocaine, Alphacaine
T0468137-58-6
Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellular adhesion molecule-1 (ICAM-1), pro-inflammatory cytokines, and reduction of neutrophils influx.
- $45
Size
QTY
Trazodone hydrochloride
Trazodone HCl, KB-831, AF-1161
T161925332-39-2
Trazodone hydrochloride (Trazodone HCl) is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety.
- $39
Size
QTY
Mianserin hydrochloride
ORG GB-94 HCl, Mianserin HCl
T078321535-47-7
Mianserin hydrochloride (Org GB 94) is a tetracyclic compound with antidepressant properties that blocks alpha-adrenergic, histamine H1, and certain serotonin receptors; it may cause drowsiness and hematological issues.
- $30
Size
QTY
Amitriptyline hydrochloride
Tryptizol, Domical, Annoyltin, Amitriptyline HCl
T0678549-18-8
Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
5-HT ReceptorAChRAdrenergic ReceptorHistamine ReceptorNorepinephrineSerotonin TransporterSigma receptorSodium ChannelTrk receptor
- $45
Size
QTY
Mirtazapine
Org3770, 6-Azamianserin
T013785650-52-8
Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.
- $34
Size
QTY
Mebhydrolin napadisylate
Omeril, Mebhydroline 1,5-naphthalenedisulfonate salt, Incidal, Diazoline, Diazolin
T01136153-33-9
Mebhydrolin napadisylate (Incidal) is an antihistamine used to relieve allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.
- $39
Size
QTY
Chlorphenesin
Gecophen, Chlorophenesin, Adermykon
T4507104-29-0
Chlorphenesin (Chlorophenesin) is an antigen-associated immunosuppressant that inhibits IgE-mediated histamine release. It is also used as an antimycotic agent.
- $37
Size
QTY
Nizatidine
Zanizal, Axid, Acinon
T157576963-41-2
Nizatidine (Acinon) is a competitive and reversible histamine H2-receptor antagonist with antacid activity.
- $29
Size
QTY
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | (R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective H3 histamine receptor agonist with a dissociation constant (Kd) of 50.3 nM. |
| Targets&IC50 | H3 receptor:50.3 nM (kd) |
| In vitro | (R)-(-)-α-Methylhistamine dihydrobromide is an H3-agonist with over 10 times the potency of histamine (HA). It exhibits weak affinities for H1 and H2 receptors, with pKi values of 4.8 and <3.5, respectively. The compound shows more than 1,000 times selectivity for H3-receptors compared to HA and over 200-fold selectivity over H4 receptors[1]. |
| In vivo | (R)-alpha-Methylhistamine dihydrochloride (6.3 mg/kg; i.p.) significantly decreases the steady-state t-MH level in the mouse brain, whereas these compounds produced no significant changes in the HA level[2].Pretreatment with (R)-(-)-α-Methylhistamine dihydrobromide reverses propofol‐induced memory retention[4]. |
| Molecular Weight | 287 |
| Formula | C6H13Br2N3 |
| Cas No. | 868698-49-1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy (R)-(-)-α-Methylhistamine dihydrobromide | purchase (R)-(-)-α-Methylhistamine dihydrobromide | (R)-(-)-α-Methylhistamine dihydrobromide cost | order (R)-(-)-α-Methylhistamine dihydrobromide | (R)-(-)-α-Methylhistamine dihydrobromide chemical structure | (R)-(-)-α-Methylhistamine dihydrobromide in vivo | (R)-(-)-α-Methylhistamine dihydrobromide in vitro | (R)-(-)-α-Methylhistamine dihydrobromide formula | (R)-(-)-α-Methylhistamine dihydrobromide molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.