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(S)-MCPG

(S)-MCPG ((+)-MCPG) is a class I/II metabotropic glutamate receptors (mGluRs) antagonist that blocks spatial learning and long-term enhancement of the dentate gyrus in vivo in rats, and can be used to study neurological disorders.

Catalog No. T13452Cas No. 150145-89-4

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Purity:98.72%

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(S)-MCPG

Catalog No. T13452Cas No. 150145-89-4

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Pack Size	Price	Availability	Quantity
1 mg	$30	In Stock
5 mg	Inquiry	In Stock

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Product Introduction

Bioactivity

Description	(S)-MCPG ((+)-MCPG) is a class I/II metabotropic glutamate receptors (mGluRs) antagonist that blocks spatial learning and long-term enhancement of the dentate gyrus in vivo in rats, and can be used to study neurological disorders.
In vivo	In male Lister-Hooded rats learning the Morris water maze, (S)-MCPG (20 μg; intraventricular injection; 4 days) impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not[2].
Alias	(+)-MCPG

Chemical Properties

Molecular Weight	209.20
Formula	C₁₀H₁₁NO₄
Cas No.	150145-89-4

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 5 mg/mL (23.90 mM), Sonication is recommended.

H2O: 80 mg/mL (382.41 mM), Sonication and adjust pH to 13 with 1M OH

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	4.7801 mL	23.9006 mL	47.8011 mL	239.0057 mL
5 mM	0.9560 mL	4.7801 mL	9.5602 mL	47.8011 mL
10 mM	0.4780 mL	2.3901 mL	4.7801 mL	23.9006 mL
20 mM	0.2390 mL	1.1950 mL	2.3901 mL	11.9503 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0956 mL	0.4780 mL	0.9560 mL	4.7801 mL
100 mM	0.0478 mL	0.2390 mL	0.4780 mL	2.3901 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

(S) MCPG(S)MCPGMCPG

(S)-MCPG

(S)-MCPG

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