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Dibutyl phthalate

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Catalog No. TN1162Cas No. 84-74-2
Alias 1,2-Benzenedicarboxylic acid

Dibutyl phthalate (1,2-Benzenedicarboxylic acid) is a plasticizer, commonly used in industrial manufacturing, that causes cardiac damage by disrupting Ca(2+) transfer from the endoplasmic reticulum to the mitochondria and triggering subsequent cellular death.Dibutyl phthalate induces oxidative damage in the brain of zebrafish.

Dibutyl phthalate

Dibutyl phthalate

🥰Excellent
Catalog No. TN1162Alias 1,2-Benzenedicarboxylic acidCas No. 84-74-2
Dibutyl phthalate (1,2-Benzenedicarboxylic acid) is a plasticizer, commonly used in industrial manufacturing, that causes cardiac damage by disrupting Ca(2+) transfer from the endoplasmic reticulum to the mitochondria and triggering subsequent cellular death.Dibutyl phthalate induces oxidative damage in the brain of zebrafish.
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100 mg$58In Stock
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Product Introduction

Bioactivity
Description
Dibutyl phthalate (1,2-Benzenedicarboxylic acid) is a plasticizer, commonly used in industrial manufacturing, that causes cardiac damage by disrupting Ca(2+) transfer from the endoplasmic reticulum to the mitochondria and triggering subsequent cellular death.Dibutyl phthalate induces oxidative damage in the brain of zebrafish.
In vitro
The compound was isolated by direct fractionation of ethyl acetate extracts of air-dried seeds and pods and subjected to microbial susceptibility testing. Antibacterial screening results show that Acacia ethyl acetate extract has the highest activity against the tested microorganisms, with an inhibition zone diameter of 27-32mm, and is effective against Salmonella typhi, Escherichia coli, Streptococcus faecalis, Staphylococcus aureus, Candida krusei and Shigella dysenteriae [1]; grass carp hepatocytes were treated with 300 μM Dibutyl phthalate for 24 h, and hepatocytes were treated with 1 μM taxolin (TAX) for 24 h to study its antagonistic effect on Dibutyl phthalate. After exposure to Dibutyl phthalate, hepatocyte oxidative stress levels and inflammation increased, and the mRNA and protein expression of apoptosis-related markers significantly increased, leading to hepatocyte apoptosis [6]; treated with 10–1000 μg/ml Dibutyl phthalate When follicles are exposed to 48 hours, Dibutyl phthalate is harmful to ovarian antral follicles when the exposure is ≥10 μg/ml. The presence of MBP does not affect the growth and vitality of Dibutyl phthalate on antral follicles [3].
In vivo
Treatment with dibutyl phthalate (DBP; 10 or 100 mg/kg/d, po) for five weeks in adult male mice induced immunotoxicity by reducing total leukocyte counts and classical monocyte and T helper cell populations, but not classical monocytogenes. Increased populations of nuclear cells and PMN-MDSCs, leading to sustained immunosuppression [2]; Dibutyl phthalate (200, 400 or 600 mg/kg/day) causes weight loss, impaired spermatogenesis, serum follicle-stimulating hormone and testosterone in mice Decreased levels, changes in testicular LDH, increased LPO and decreased enzyme antioxidant levels, accompanied by histopathological abnormalities [4]; Dibutyl phthalate (6.25, 12.5, 25, 50, 100 and 200mg/kg) may produce Some neurobehavioral adverse effects [5].
Alias1,2-Benzenedicarboxylic acid
Chemical Properties
Molecular Weight278.34
FormulaC16H22O4
Cas No.84-74-2
SmilesO=C(OCCCC)C=1C=CC=CC1C(=O)OCCCC
Relative Density.1.043 g/cm3 at 25℃ (lit.)
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 30 mg/mL (107.78 mM)
DMSO: 80 mg/mL (287.42 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM3.5927 mL17.9636 mL35.9273 mL179.6364 mL
5 mM0.7185 mL3.5927 mL7.1855 mL35.9273 mL
10 mM0.3593 mL1.7964 mL3.5927 mL17.9636 mL
20 mM0.1796 mL0.8982 mL1.7964 mL8.9818 mL
50 mM0.0719 mL0.3593 mL0.7185 mL3.5927 mL
100 mM0.0359 mL0.1796 mL0.3593 mL1.7964 mL

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