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5-Chloro-2'-deoxyuridine

5-Chloro-2'-deoxyuridine (5-Chlorodeoxyuridine) is a thymine analog. It can be used to study the potential of hypochlorous acid damage to DNA and DNA precursors.

Catalog No. T19151Cas No. 50-90-8

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Purity:100.00%

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COA HNMR LCMS

5-Chloro-2'-deoxyuridine

Catalog No. T19151Cas No. 50-90-8

5-Chloro-2'-deoxyuridine (5-Chlorodeoxyuridine) is a thymine analog. It can be used to study the potential of hypochlorous acid damage to DNA and DNA precursors.

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Pack Size	Price	Availability
25 mg	$30	In Stock
50 mg	$40	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Product Introduction

Bioactivity

Description	5-Chloro-2'-deoxyuridine (5-Chlorodeoxyuridine) is a thymine analog. It can be used to study the potential of hypochlorous acid damage to DNA and DNA precursors.
In vitro	The mammalian cells incorporate the analog into DNA when 5-Chloro-2’-deoxyuridine (ClDU) is placed into the tissue culture medium. It is observed that a 10 μM concentration of 5-Chloro-2’-deoxyuridine in the media does not alter cell division kinetics. Previously it has been shown that 5-Chloro-2’-deoxyuridine is metabolized and incorporated into DNA using antibodies that bind selectively to DNA containing halogenated bases. In this study, 5-Chloro-2’-deoxyuridine is more similar to BrdU in acting as a T analog. The toxicity of 5-Chloro-2’-deoxyuridine could in part be attributed to inhibition of thymidylate synthase [1].
Alias	5-Chlorodeoxyuridine, CldU

Chemical Properties

Molecular Weight	262.65
Formula	C₉H₁₁ClN₂O₅
Cas No.	50-90-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 125 mg/mL (475.92 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8073 mL	19.0367 mL	38.0735 mL	190.3674 mL
5 mM	0.7615 mL	3.8073 mL	7.6147 mL	38.0735 mL
10 mM	0.3807 mL	1.9037 mL	3.8073 mL	19.0367 mL
20 mM	0.1904 mL	0.9518 mL	1.9037 mL	9.5184 mL
50 mM	0.0761 mL	0.3807 mL	0.7615 mL	3.8073 mL
100 mM	0.0381 mL	0.1904 mL	0.3807 mL	1.9037 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Inhibitorinhibit5Chloro2'deoxyuridine5-Chloro-2'-deoxyuridine5 Chloro 2' deoxyuridine