Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

8-M-PDOT

Catalog No. T10198Cas No. 134865-70-6
Alias AH-002, 8-Methoxy-2-propionamidotetralin

8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors. 8-M-PDOT exhibits anxiolytic activity and can be used to study MT2-induced neuropathic pain.

8-M-PDOT

8-M-PDOT

Purity: 99.54%
Catalog No. T10198Alias AH-002, 8-Methoxy-2-propionamidotetralinCas No. 134865-70-6
8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors. 8-M-PDOT exhibits anxiolytic activity and can be used to study MT2-induced neuropathic pain.
Pack SizePriceAvailabilityQuantity
1 mg$305 days
5 mg$64In Stock
10 mg$118In Stock
1 mL x 10 mM (in DMSO)$715 days
Bulk & Custom
Add to Cart
Questions
View More
Select Batch
Purity:99.54%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors. 8-M-PDOT exhibits anxiolytic activity and can be used to study MT2-induced neuropathic pain.
Targets&IC50
MT2 receptor:8.23 (pKi), MT1 receptor:8.95 (pKi)
In vivo
Treatment with 8-M-PDOT (10 µg/µL; administered into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) demonstrates an anxiolytic-like effect[2].
Animal Research
Animal Model: Male Wistar rats (280-320 g) with Rotenone [2]. Dosage: 10 μg/μL. Administration: Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes
AliasAH-002, 8-Methoxy-2-propionamidotetralin
Chemical Properties
Molecular Weight233.31
FormulaC14H19NO2
Cas No.134865-70-6
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (214.31 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.2861 mL21.4307 mL42.8614 mL214.3071 mL
5 mM0.8572 mL4.2861 mL8.5723 mL42.8614 mL
10 mM0.4286 mL2.1431 mL4.2861 mL21.4307 mL
20 mM0.2143 mL1.0715 mL2.1431 mL10.7154 mL
50 mM0.0857 mL0.4286 mL0.8572 mL4.2861 mL
100 mM0.0429 mL0.2143 mL0.4286 mL2.1431 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy 8-M-PDOT | purchase 8-M-PDOT | 8-M-PDOT cost | order 8-M-PDOT | 8-M-PDOT chemical structure | 8-M-PDOT in vivo | 8-M-PDOT formula | 8-M-PDOT molecular weight