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8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors. 8-M-PDOT exhibits anxiolytic activity and can be used to study MT2-induced neuropathic pain.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | 5 days | |
5 mg | $64 | In Stock | |
10 mg | $118 | In Stock | |
1 mL x 10 mM (in DMSO) | $71 | 5 days |
Description | 8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors. 8-M-PDOT exhibits anxiolytic activity and can be used to study MT2-induced neuropathic pain. |
Targets&IC50 | MT2 receptor:8.23 (pKi), MT1 receptor:8.95 (pKi) |
In vivo | Treatment with 8-M-PDOT (10 µg/µL; administered into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) demonstrates an anxiolytic-like effect[2]. |
Animal Research | Animal Model: Male Wistar rats (280-320 g) with Rotenone [2]. Dosage: 10 μg/μL. Administration: Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes |
Alias | AH-002, 8-Methoxy-2-propionamidotetralin |
Molecular Weight | 233.31 |
Formula | C14H19NO2 |
Cas No. | 134865-70-6 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (214.31 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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