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Ramelteon

Ramelteon
Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.
Catalog No. T1463Cas No. 196597-26-9
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Purity:99.92%
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Ramelteon

Purity: 99.92%
Catalog No. T1463Alias TAK-375Cas No. 196597-26-9

Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
2 mg$37In Stock
5 mg$59In Stock
10 mg$80In Stock
25 mg$138In Stock
50 mg$213In Stock
100 mg$343In Stock
500 mg$539In Stock
1 mL x 10 mM (in DMSO)$65In Stock
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Product Introduction

Bioactivity
Description
Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.
Targets&IC50
MT receptor (chicken):23.1 pM(Ki), MT2 receptor:112 pM(Ki), MT1 receptor:14 pM(Ki)
Kinase Assay
cDNA encoding the human MT1 gene is introduced into CHO cells. Cells are harvested at confluence in Ca2+ and Mg2+ free Hanks' balanced salt solution containing 5 mM EDTA and collected by centrifugation. Cells are homogenized in ice-cold 50 mM Tris–HCl buffer, washed twice, pelleted, and stored at -30°C until the binding assays are conducted. Test compound and 40 pM 2-[ 125I]melatonin are mixed with the thawed homogenate in a total volume of 1 mL and incubated at 25°C for 150 min. The reaction is terminated by addition of 3 mL of icecold buffer followed by vacuum filtration on a Whatman GF/B. The filter is washed twice and radioactivity is counted by a g-counter[1].
AliasTAK-375
Chemical Properties
Molecular Weight259.34
FormulaC16H21NO2
Cas No.196597-26-9
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 49 mg/mL (188.9 mM)
DMSO: 60 mg/mL (231.36 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM3.8559 mL19.2797 mL38.5594 mL192.7971 mL
5 mM0.7712 mL3.8559 mL7.7119 mL38.5594 mL
10 mM0.3856 mL1.9280 mL3.8559 mL19.2797 mL
20 mM0.1928 mL0.9640 mL1.9280 mL9.6399 mL
50 mM0.0771 mL0.3856 mL0.7712 mL3.8559 mL
100 mM0.0386 mL0.1928 mL0.3856 mL1.9280 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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