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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $37 | In Stock | |
5 mg | $59 | In Stock | |
10 mg | $80 | In Stock | |
25 mg | $138 | In Stock | |
50 mg | $213 | In Stock | |
100 mg | $343 | In Stock | |
500 mg | $539 | In Stock | |
1 mL x 10 mM (in DMSO) | $65 | In Stock |
Description | Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist. |
Targets&IC50 | MT receptor (chicken):23.1 pM(Ki), MT2 receptor:112 pM(Ki), MT1 receptor:14 pM(Ki) |
Kinase Assay | cDNA encoding the human MT1 gene is introduced into CHO cells. Cells are harvested at confluence in Ca2+ and Mg2+ free Hanks' balanced salt solution containing 5 mM EDTA and collected by centrifugation. Cells are homogenized in ice-cold 50 mM Tris–HCl buffer, washed twice, pelleted, and stored at -30°C until the binding assays are conducted. Test compound and 40 pM 2-[ 125I]melatonin are mixed with the thawed homogenate in a total volume of 1 mL and incubated at 25°C for 150 min. The reaction is terminated by addition of 3 mL of icecold buffer followed by vacuum filtration on a Whatman GF/B. The filter is washed twice and radioactivity is counted by a g-counter[1]. |
Alias | TAK-375 |
Molecular Weight | 259.34 |
Formula | C16H21NO2 |
Cas No. | 196597-26-9 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 49 mg/mL (188.9 mM) DMSO: 60 mg/mL (231.36 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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