Shopping Cart

Remove All

Your shopping cart is currently empty

4-P-PDOT

Select Batch

Purity:99.68%

Resource Download

COA HNMR HPLC

4-P-PDOT

Catalog No. T14042Cas No. 134865-74-0

4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$72	In Stock
10 mg	$113	In Stock
25 mg	$223	In Stock
50 mg	$413	In Stock
100 mg	$618	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "4-P-PDOT"

Product Introduction

Bioactivity

Description	4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.
In vitro	In CHO-mt1 cells the amidotetraline 4-P-PDOT (10 mM) has no effect on forskolin-stimulated cyclic AMP levels, either alone, or in the presence of Melatonin. However, in CHO-MT2 cells, 4-P-PDOT is an agonist, producing a concentration-dependent inhibition of forskolin stimulated cyclic AMP, with a pEC50 value of 8.72 and intrinsic activity of 0.86[1].
In vivo	4-P-PDOT (0.5-1.0 mg/kg; intravenous injection; klotho mutant mice) treatment significantly reverses antioxidant effects mediated by Melatonin. And significantly reverses the changes in the levels of these GSH-related parameters. 4-P-PDOT also counteracts Melatonin-mediated attenuation in response to the decreases in phospho-ERK expression, Nrf2 nuclear translocation, Nrf2 DNA-binding activity, and GCL mRNA expression in the hippocampi of klotho mutant mice[2]. 4-P-PDOT treatment significantly reverses the memory function of Melatonin-treated klotho mutant mice.
Alias	4-phenyl-2- propionamidotetralin

Chemical Properties

Molecular Weight	279.38
Formula	C19H21NO
Cas No.	134865-74-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 41.67 mg/mL (149.15 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5794 mL	17.8968 mL	35.7935 mL	178.9677 mL
5 mM	0.7159 mL	3.5794 mL	7.1587 mL	35.7935 mL
10 mM	0.3579 mL	1.7897 mL	3.5794 mL	17.8968 mL
20 mM	0.1790 mL	0.8948 mL	1.7897 mL	8.9484 mL
50 mM	0.0716 mL	0.3579 mL	0.7159 mL	3.5794 mL
100 mM	0.0358 mL	0.1790 mL	0.3579 mL	1.7897 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc