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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $81 | In Stock | |
5 mg | $197 | In Stock | |
10 mg | $318 | In Stock | |
25 mg | $562 | In Stock | |
50 mg | $787 | In Stock | |
100 mg | $1,080 | In Stock | |
1 mL x 10 mM (in DMSO) | $217 | In Stock |
Description | ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2. |
Targets&IC50 | MT1:0.06 nM(EC50), MT2:0.32 nM(EC50) |
In vitro | ACH-000143 demonstrated subnanomolar potency at MT1/MT2 receptors, high oral bioavailability in rodents, peripherally preferred exposure, and excellent selectivity in a broad panel of targets. |
In vivo | Two-month oral administration of ACH-000143 in high-fat diet rats led to a reduction in body weight gain similar to dapagliflozin with superior results on hepatic steatosis and triglyceride levels. |
Molecular Weight | 297.74 |
Formula | C13H16ClN3O3 |
Cas No. | 2225836-30-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/ml (201.52 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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