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ACH-000143
Catalog No. T9193Cas No. 2225836-30-4
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
ACH-000143
Catalog No. T9193Cas No. 2225836-30-4
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 5 mg | $118 | In Stock | |
| 10 mg | $191 | In Stock | |
| 25 mg | $337 | In Stock | |
| 50 mg | $472 | In Stock | |
| 100 mg | $648 | In Stock | |
| 200 mg | $873 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $130 | In Stock |
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CitedSelect Batch
Purity:98.15%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2. |
| Targets&IC50 | MT1:0.06 nM(EC50), MT2:0.32 nM(EC50) |
| In vitro | ACH-000143 demonstrated subnanomolar potency at MT1/MT2 receptors, high oral bioavailability in rodents, peripherally preferred exposure, and excellent selectivity in a broad panel of targets. |
| In vivo | Two-month oral administration of ACH-000143 in high-fat diet rats led to a reduction in body weight gain similar to dapagliflozin with superior results on hepatic steatosis and triglyceride levels. |
| Molecular Weight | 297.74 |
| Formula | C13H16ClN3O3 |
| Cas No. | 2225836-30-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/ml (201.52 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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