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AM12
😃Good
Catalog No. T13546Cas No. 2387510-84-9
AM12 inhibits lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).
AM12
😃Good
Catalog No. T13546Cas No. 2387510-84-9
AM12 inhibits lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $475 | 35 days | |
| 50 mg | $1,990 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AM12 inhibits lanthanide-evoked TRPC5 activity (IC50: 0.28 μM). |
| Targets&IC50 | TRPC5:0.28 μM |
| In vitro | AM12 inhibits TRPC5 and TRPC4 channel activities evoked by the agonist (-)-Englerin A via a site accessible from the extracellular face of the membrane, acting directly on either the channel or a closely associated site. It also inhibits Ca2+ entry evoked by Gd3+, with an IC50 of 0.28 μM, demonstrating slightly higher potency than the natural product Galangin. |
| Molecular Weight | 349.13 |
| Formula | C15H9BrO5 |
| Cas No. | 2387510-84-9 |
| Relative Density. | 1.864 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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