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AM404
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Catalog No. T39281Cas No. 183718-77-6
Alias AM 404
AM404 is an endocannabinoid reuptake inhibitor, a TRPV(1) activator, a paracetamol metabolite, with neuroprotective and anticancer activity that blocks anandamide transport. AM404 inhibits NFAT and NF-kappaB signaling pathways and impairs migration and invasiveness of neuroblastoma cells, preventing prostaglandin synthesis in activated microglia by inhibiting COX activity.
AM404
😃Good
Catalog No. T39281Alias AM 404Cas No. 183718-77-6
AM404 is an endocannabinoid reuptake inhibitor, a TRPV(1) activator, a paracetamol metabolite, with neuroprotective and anticancer activity that blocks anandamide transport. AM404 inhibits NFAT and NF-kappaB signaling pathways and impairs migration and invasiveness of neuroblastoma cells, preventing prostaglandin synthesis in activated microglia by inhibiting COX activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg（126.4 mM * 100 μL in Ethanol） | $63 | 35 days | |
| 10 mg（126.4 mM * 200 μL in Ethanol） | $113 | 35 days | |
| 50 mg（126.4 mM * 1 mL in Ethanol） | $465 | 35 days | |
| 100 mg（126.4 mM * 2 mL in Ethanol） | $793 | 35 days |
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CitedSelect Batch
Concentration:50.0 mg/mL
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Product Introduction
Bioactivity
Chemical Properties
| Description | AM404 is an endocannabinoid reuptake inhibitor, a TRPV(1) activator, a paracetamol metabolite, with neuroprotective and anticancer activity that blocks anandamide transport. AM404 inhibits NFAT and NF-kappaB signaling pathways and impairs migration and invasiveness of neuroblastoma cells, preventing prostaglandin synthesis in activated microglia by inhibiting COX activity. |
| Targets&IC50 | C6 glioma cells:4.9 μM |
| In vitro | At the concentration used to block cellular accumulation of the endogenous cannabinoid anandamide, AM404 nonspecifically inhibited the proliferation of C6 glioma cells, with an IC50 = 4.9 μM for C6 glioma cells. [2] |
| In vivo | Intraperitoneal injections of 1-5 mg/kg AM404 showed dose-dependent anxiolytic-like effects in the elevated cross maze, defensive withdrawal, and separation-induced ultrasonic vocalizations, the three models. Intraperitoneal injection of 2.5-10 mg/kg AM404 resulted in a dose-dependent increase in anandamide levels in the prefrontal cortex, hippocampus and thalamus of adult male Sprague-Dawley rats. [2] |
| Alias | AM 404 |
| Molecular Weight | 395.58 |
| Formula | C26H37NO2 |
| Cas No. | 183718-77-6 |
| Smiles | N(C(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)C1=CC=C(O)C=C1 |
| Relative Density. | 1.007 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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