AZ-23
Catalog No. T14363 CAS
915720-21-7
Synonyms:
AZ 23, AZ23
AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.
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Biological Description
Chemical Properties
Storage
& Solubility Information
Description |
AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively. |
Targets&IC50 |
TrkB:8 nM, TrkA:2 nM
|
In vitro |
AZ-23 potently and selectivity inhibits Trk phosphorylation in cells. AZ-23 potently inhibits Trk-mediated survival (EC50 of 2 nM) and it also Inhibits Trk-Dependent Survival in MCF10ATrkA-Δ and TF-1 Cell Lines[1]. |
In vivo |
AZ-23 shows in vivo TrkA kinase inhibition and efficacy in mice following oral administration in a TrkA-driven allograft model. And it significant tumor growth inhibition in a Trk-expressing xenograft model of neuroblastoma[1]. |
Synonyms |
AZ 23, AZ23
|
Molecular Weight |
391.83
|
Formula |
C17H19ClFN7O |
CAS No. |
915720-21-7 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
DMSO: 125 mg/mL (319.02 mM),
Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Keywords
AZ-23
915720-21-7
蛋白酪氨酸激酶
Trk receptor
AZ23
Tropomyosin related kinase receptor
AZ 23
Inhibitor
inhibit
Trk Receptor
inhibitor