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AZ-23

Catalog No. T14363 CAS 915720-21-7

Synonyms: AZ 23, AZ23

AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.

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AZ-23, CAS 915720-21-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.
Targets&IC50	TrkB:8 nM, TrkA:2 nM
In vitro	AZ-23 potently and selectivity inhibits Trk phosphorylation in cells. AZ-23 potently inhibits Trk-mediated survival (EC50 of 2 nM) and it also Inhibits Trk-Dependent Survival in MCF10ATrkA-Δ and TF-1 Cell Lines[1].
In vivo	AZ-23 shows in vivo TrkA kinase inhibition and efficacy in mice following oral administration in a TrkA-driven allograft model. And it significant tumor growth inhibition in a Trk-expressing xenograft model of neuroblastoma[1].

Synonyms	AZ 23, AZ23
Molecular Weight	391.83
Formula	C17H19ClFN7O
CAS No.	915720-21-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 125 mg/mL (319.02 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Thress K, et al. Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway. Mol Cancer Ther. 2009 Jul; 8(7):1818-27.

Related Products

Related compounds with same targets

3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one LOXO-195 ALE-0540 LM22A-4 Larotrectinib BMS-754807 PF-06737007 Trk-IN-4

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AZ-23 915720-21-7 蛋白酪氨酸激酶 Trk receptor AZ23 Tropomyosin related kinase receptor AZ 23 Inhibitor inhibit Trk Receptor inhibitor

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