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ALE-0540

Catalog No. T9292 CAS 234779-34-1

Synonyms: ALE0540

ALE-0540 is a nonpeptidic heterocyclic molecule that inhibits the binding of NGF to p75 and TrkA, as well as signal transduction and biological responses mediated by TrkA receptors.

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ALE-0540, CAS 234779-34-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

ALE-0540 is a nonpeptidic heterocyclic molecule that inhibits the binding of NGF to p75 and TrkA, as well as signal transduction and biological responses mediated by TrkA receptors.

In vivo

Either i.p. or i.th. administration of ALE-0540 in rats produced antiallodynia in the L5/L6 ligation model of neuropathic pain. The calculated A50 values (and 95% confidence intervals) for ALE-0540 administered i.p. and i.th. were 38 (17.5–83) mg/kg and 34.6 (17.3–69.4) mg, respectively. ALE-0540 given i.th., at doses of 30 and 60 mg, also blocked tactile allodynia in the thermal sensitization model.

Synonyms	ALE0540
Molecular Weight	301.258
Formula	C14H11N3O5
CAS No.	234779-34-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Owolabi JB, Rizkalla G, Tehim A, Ross GM, Riopelle RJ, Kamboj R, Ossipov M, Bian D, Wegert S, Porreca F, Lee DK. Characterization of antiallodynic actions of ALE-0540, a novel nerve growth factor receptor antagonist, in the rat. J Pharmacol Exp Ther. 1999 Jun;289(3):1271-6. PMID: 10336516.

Related Products

Related compounds with same targets

3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one LOXO-195 ALE-0540 LM22A-4 Larotrectinib BMS-754807 PF-06737007 Trk-IN-4

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ALE-0540 234779-34-1 Tyrosine Kinase/Adaptors Trk receptor ALE0540 Inhibitor inhibitor inhibit

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