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Alisol A 23-acetate
Catalog No. TN6704Cas No. 19865-75-9
Alisol A 23-acetate may possess therapeutic effects through their modulation of AR, PR, and GR pathways.
Alisol A 23-acetate
Catalog No. TN6704Cas No. 19865-75-9
Alisol A 23-acetate may possess therapeutic effects through their modulation of AR, PR, and GR pathways.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $670 | Backorder | |
| 1 mL x 10 mM (in DMSO) | $1,010 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Alisol A 23-acetate may possess therapeutic effects through their modulation of AR, PR, and GR pathways. |
| In vitro | METHODS AND RESULTS: Two triterpenes, alisol M 23-acetate and Alisol A 23-acetate from Alisma orientalis were determined whether they may act as androgen receptor (AR), progesterone receptor (PR), or glucocorticoid receptor (GR) modulators. Indeed, in the transient transfection reporter assays, alisol M 23-acetate and Alisol A 23-acetate transactivated AR in dose-dependent manner, while they transrepressed the transactivation effects exerted by agonist-activated PR and GR. Through molecular modeling docking studies, they were shown to respectively interact with AR, PR, or GR ligand binding pocket fairly well. CONCLUSIONS: All these results indicate that alisol M 23-acetate and Alisol A 23-acetate from Alisma orientalis might possess therapeutic effects through their modulation of AR, PR, and GR pathways. |
| Molecular Weight | 532.762 |
| Formula | C32H52O6 |
| Cas No. | 19865-75-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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