Alisol F 24-acetate, a natural product isolated from Alisma plantago-aquatica Linn[1], enhances chemosensitivity and apoptosis of MCF-7 DOX Cells by inhibiting P-Glycoprotein-Mediated drug efflux[2].
Alisol C 23-acetate (Alisol C monoacetate) is a natural product isolated from Alisma orientale, can significantly and strongly inhibit DTH response after oral administration,has antibacterial activity.
Alisol B may be a potential novel therapeutic molecule for bone disorders through targeting the differentiation of osteoclasts as well as their functions. Alisol B also inhibited RANKL-induced expression of NFATc1 and c-Fos, which are key transcription factors for osteoclastogenesis.
1. Alisol B 23-acetate (Alisol B Acetate) produces protective effect against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes. 2. Alisol B 23-acetate produces promotive effect on liver regeneration, due to FXR-mediated regulation of genes involved in hepatocyte proliferation and hepato-protection. 3. Alisol B 23-acetate produces a protective effect against CCl4-induced hepatotoxicity, due to FXR and STAT3-mediated gene regulation.
Alisol B acetate can induce Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells, the Bax activation and translocation from the cytosol to nucleus might be a crucial response to the apoptotic effect. Alisol B aceta
Alisol O is a natural product of Alisma, Alismataceae. The catalog number is TN3377 and the CAS number is 928148-51-0. Alisol O can be used as a reference standard.
1alpha,4beta,10beta-Trihydroxyguaia-2,11(13)-dien-12,6alpha-olide is a natural product of Alisma, Alismataceae. The catalog number is TN2665 and the CAS number is 221148-94-3. 1alpha,4beta,10beta-Trihydroxyguaia-2,11(13)-dien-12,6alpha-olide can be used as a reference standard.
Alisol A (Alisol-A) may be an autophagic inducer, it has anti-cancer activity, it presents inhibitory effects on cancer cell lines tested(HepG2, MDA-MB-231, and MCF-7 cells).
Alisol C can improve glucose uptake in Hep G2 cells, it may be one of the therapeutic material basis in hypoglycemic activities in A. orientalis. Alisol C,16,23-oxido-alisol B and alisol O in Zexie may cause nephrotoxicity.
Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for the prevention of anginal attacks.