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Amitifadine hydrochloride

Catalog No. T2092 CAS 410074-74-7

Synonyms: inhibit, Amitifadine hydrochloride, Inhibitor, SERT, Amitifadine, EB 1010, DOV-21947 hydrochloride, DOV21947, DOV 21947, DOV-21947, SLC6A3, 5-HTT, EB-1010, EB1010, Serotonin Transporter, DAT, SLC6A4, EB-1010 hydrochloride, Dopamine Transporter

Amitifadine hydrochloride is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Amitifadine hydrochloride, CAS 410074-74-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Amitifadine hydrochloride is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).
Targets&IC50	norepinephrine(in HEK 293 cells):23 nM, dopamine(in HEK 293 cells):96 nM, serotonin(in HEK 293 cells):12 nM

Synonyms	inhibit, Amitifadine hydrochloride, Inhibitor, SERT, Amitifadine, EB 1010, DOV-21947 hydrochloride, DOV21947, DOV 21947, DOV-21947, SLC6A3, 5-HTT, EB-1010, EB1010, Serotonin Transporter, DAT, SLC6A4, EB-1010 hydrochloride, Dopamine Transporter
Molecular Weight	264.57
Formula	C11H12Cl3N
CAS No.	410074-74-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Skolnick P, et al. Eur J Pharmacol. 2003 Feb 14;461(2-3):99-104.

Related compound libraries

This product is contained In the following compound libraries：

Preclinical Compound Library GPCR Compound Library Serotonin Receptor-Targeted Compound Library Anti-Obesity Compound Library Neurotransmitter Receptor Compound Library Anti-Parkinson's Disease Compound Library Inhibitor Library Drug Repurposing Compound Library Neuronal Signaling Compound Library Anti-Neurodegenerative Disease Compound Library

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.