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SB-277011 dihydrochloride
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Catalog No. T12861LCas No. 1226917-67-4
Alias SB-277011A dihydrochloride
SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively).
SB-277011 dihydrochloride
😃Good
Catalog No. T12861LAlias SB-277011A dihydrochlorideCas No. 1226917-67-4
SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $110 | 35 days | |
| 5 mg | $295 | 35 days | |
| 10 mg | $483 | 35 days | |
| 25 mg | $1,060 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively). |
| Targets&IC50 | 5-HT1B receptor:<5.2 (pki), D3 receptor:pki： 8.0 , D2 receptor:6 (pki), 5-HT1D receptor:5.9(pki) |
| In vitro | SB-277011 dihydrochloride is a selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor, and restores ≥100-fold selectivity against the D2, 5-HT1B, and 5-HT1D receptors(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively). |
| In vivo | the effects of quinelorane in the nucleus accumbens completely reversed by SB-277011 dihydrochloride (SB 277011; 3 mg/kg, p.o.), but does not reverse the effects of quinelorane in the striatum at 93 mg/kg in rats. |
| Alias | SB-277011A dihydrochloride |
| Molecular Weight | 511.49 |
| Formula | C28H32Cl2N4O |
| Cas No. | 1226917-67-4 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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