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BGB-102

Catalog No. T10531 CAS 807640-87-5

Synonyms: JNJ-26483327

Purity 98.00% Datasheet

BGB-102 is a potent multi-kinase inhibitor against HER2, EGFR, and HER4 (IC50s: 18 nM, 9.6 nM, and 40.3 nM).

BGB-102, CAS 807640-87-5

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Purity 98.00%

Datasheet

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BGB-102 is a potent multi-kinase inhibitor against HER2, EGFR, and HER4 (IC50s: 18 nM, 9.6 nM, and 40.3 nM).
Targets&IC50	EGFR :ic50 9.6 nM, HER2 :ic50 18 nM, HER4 :ic50 40.3 nM,
In vivo	Compared to vehicle treatment, JNJ-26483327 (75 mg/kg, p.o.) delays xenograft tumor growth, but when combines with Herceptin, they can abrogate the PKB feedback loop and is synergistic in inhibition of xenograft tumor growth.

Synonyms	JNJ-26483327
Purity	98.00%
Molecular Weight	457.36
Formula	C22H25BrN4O2
CAS No.	807640-87-5

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Gijsen M, et al. HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer. PLoS Biol. 2010 Dec 21;8(12):e1000563.

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.