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BMS-564929

Catalog No. T14675 CAS 627530-84-1

BMS-564929 is an agonist of androgen receptor (AR, Ki of 2.11±0.16 nM).

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BMS-564929, CAS 627530-84-1

Pack Size	Availability	Price/USD	Quantity
50 mg	6-8 weeks	$ 717.00
100 mg	6-8 weeks	$ 996.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BMS-564929 is an agonist of androgen receptor (AR, Ki of 2.11±0.16 nM).
Targets&IC50	Androgen receptor:（ki）2.11±0.16 nM
In vitro	BMS-564929 exhibits high selectivity, being over 1000-fold more selective for androgen receptors (AR) compared to estrogen receptors (ER) α and β, glucocorticoid receptor (GR), and mineralocorticoid receptor (MR), with about 400-fold selectivity against progesterone receptor (PR). It demonstrates no measurable activity in functional transactivation assays involving ERα/β, GR, MR, or PR at concentrations up to 30 μM. Furthermore, BMS-564929 shows potent activity in the C2C12 myoblast cell line, with an EC50 (the concentration needed to achieve 50% of the maximum stimulatory effect of DHT) of 0.44±0.03 nM, and in the PEC cell line, the EC50 is 8.66±0.22 nM.
In vivo	BMS-564929 demonstrates a significant enhancement in muscle stimulation potency, being over 200 times more effective than T propionate (TP) and 80 times more selective in targeting muscle versus prostate in the evaluated model[1]. Administered orally, BMS-564929 showcases superior efficacy in the levator ani muscle, with an ED50 of 0.0009 mg/kg, compared to its ED50 of 0.14 mg/kg in the prostate, indicating a notable 160-fold preference for muscle over prostate in sexually mature, castrated male rats—a thoroughly studied animal model. Remarkably, muscle stimulation peaks at approximately 100% with a dose of 0.1 mg/kg and exceeds 125% at higher doses of 0.3 and 1 mg/kg.

Molecular Weight	305.72
Formula	C14H12ClN3O3
CAS No.	627530-84-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (163.55 mM), Sonification is recommended.

References and Literature

1. Ostrowski J, et al. Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats. Endocrinology. 2007 Jan;148(1):4-12.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMS-564929 627530-84-1 Endocrinology/Hormones Androgen Receptor BMS564929 BMS 564929 inhibitor inhibit

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