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BMS-779788

BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).

Catalog No. T3970Cas No. 918348-67-1

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Purity:99.24%

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COA HPLC HNMR

BMS-779788

Catalog No. T3970Cas No. 918348-67-1

BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

Pack Size	Price	Availability
2 mg	$32	In Stock
5 mg	$51	In Stock
10 mg	$76	In Stock
25 mg	$159	In Stock
50 mg	$263	In Stock
100 mg	$413	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock

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Product Introduction

Bioactivity

Description	BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).
Targets&IC50	LXRβ:14 nM, LXRα:68nM
In vitro	BMS-779788 can effectively induce ATP binding transporters ABCA1 and ABCG1 in the human whole blood (EC50: 1.2 μM).
In vivo	BMS-779788 has an inducted effect of LXR target genes in blood in vivo (EC50: 610 nM). In elevating plasma triglyceride and LDL cholesterol, BMS-779788 is 29- and 12-fold less potent than the full agonist T0901317 respectively[1]. In mice, BMS-779788 displayed peripheral induction of ABCA1 at 3 and 10mpk doses with no significant elevation of plasma or hepatic triglycerides at these doses, showing an improved profile compared to a full pan-agonist[2].
Alias	XL652, EXEL04286652, XL 652, XL-652, BMS-788

Chemical Properties

Molecular Weight	509.06
Formula	C₂₈H₂₉ClN₂O₃S
Cas No.	918348-67-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 60 mg/mL (117.86 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9644 mL	9.8220 mL	19.6440 mL	98.2202 mL
5 mM	0.3929 mL	1.9644 mL	3.9288 mL	19.6440 mL
10 mM	0.1964 mL	0.9822 mL	1.9644 mL	9.8220 mL
20 mM	0.0982 mL	0.4911 mL	0.9822 mL	4.9110 mL
50 mM	0.0393 mL	0.1964 mL	0.3929 mL	1.9644 mL
100 mM	0.0196 mL	0.0982 mL	0.1964 mL	0.9822 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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