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BMS-779788

Catalog No. T3970 CAS 918348-67-1

Synonyms: XL652, EXEL04286652, XL 652, XL-652, BMS-788

BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).

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BMS-779788, CAS 918348-67-1

Pack Size	Availability	Price/USD
2 mg	In stock	$ 32.00
5 mg	In stock	$ 51.00
10 mg	In stock	$ 76.00
25 mg	In stock	$ 159.00
50 mg	In stock	$ 263.00
100 mg	In stock	$ 413.00
1 mL * 10 mM (in DMSO)	In stock	$ 58.00

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Purity: 99.24%

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Description	BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).
Targets&IC50	LXRβ:14 nM, LXRα:68nM
In vitro	BMS-779788 can effectively induce ATP binding transporters ABCA1 and ABCG1 in the human whole blood (EC50: 1.2 μM).
In vivo	BMS-779788 has an inducted effect of LXR target genes in blood in vivo (EC50: 610 nM). In elevating plasma triglyceride and LDL cholesterol, BMS-779788 is 29- and 12-fold less potent than the full agonist T0901317 respectively[1]. In mice, BMS-779788 displayed peripheral induction of ABCA1 at 3 and 10mpk doses with no significant elevation of plasma or hepatic triglycerides at these doses, showing an improved profile compared to a full pan-agonist[2].

Synonyms	XL652, EXEL04286652, XL 652, XL-652, BMS-788
Molecular Weight	509.06
Formula	C28H29ClN2O3S
CAS No.	918348-67-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (117.86 mM)

References and Literature

1. Kick, E., Martin, R., Xie, Y., Flatt, B., Schweiger, E., & Wang, T. et al. (2015). Liver X Receptor (LXR) partial agonists: Biaryl pyrazoles and imidazoles displaying a preference for LXRβ. Bioorganic & Medicinal Chemistry Letters, 25(2), 372-377. doi: 10.1016/j.bmcl.2014.11.029

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Lipid Metabolism Compound Library ReFRAME Related Library Metabolism Compound Library NO PAINS Compound Library Clinical Compound Library Bioactive Compounds Library Max Anti-Metabolism Disease Compound Library Bioactive Compound Library Nuclear Receptor Compound Library

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Related compounds with same targets

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMS-779788 918348-67-1 Metabolism Liver X Receptor Inhibitor BMS 788 Liver X receptor XL652 inhibit EXEL 04286652 BMS779788 LXR EXEL04286652 XL 652 EXEL-04286652 XL-652 BMS-788 BMS788 BMS 779788 inhibitor

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