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Bifluranol

Catalog No. T14843 CAS 34633-34-6

Synonyms: BX341

Bifluranol (BX341) has anti-androgenic activity and has shown significant anti-prostatic activity in in vivo studies for the treatment of benign prostatic hyperplasia (BPH).

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Bifluranol, CAS 34633-34-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 339.00
5 mg	In stock	$ 813.00
10 mg	In stock	$ 1,370.00
25 mg	In stock	$ 2,870.00
50 mg	In stock	$ 4,570.00
100 mg	In stock	$ 6,180.00

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Purity: 99.77%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Bifluranol (BX341) has anti-androgenic activity and has shown significant anti-prostatic activity in in vivo studies for the treatment of benign prostatic hyperplasia (BPH).

In vivo

Bifluranol has been studied for its absorption, distribution, and excretion in mouse, rat, ferret, and dog. Following oral administration, Bifluranol is readily absorbed, but its blood concentrations are low due to hepatic uptake and biliary excretion.
After the intravenous administration of [3H]Bifluranol at doses of 200 μg/kg in rats and 60 μg/kg in ferrets, the blood concentrations of 3H decline rapidly during the first 2 to 3 hours. The decrease is more rapid in females (18 min for rats, 30 min for ferrets) than in males (1.0 h for rats, 1.4 h for ferrets). This initial rapid decline is followed by a much slower decrease (40 h for rats, 20 h for ferrets) to concentrations at 96 hours of less than 15 ng Bifluranol equivalents mL-1 (rat) or 1 ng Bifluranol equivalents mL-1 (ferret)[1].

Synonyms	BX341
Molecular Weight	292.32
Formula	C17H18F2O2
CAS No.	34633-34-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (307.88 mM), Sonication is recommended.

References and Literature

1. Pope DJ, et al. Bifluranol, a novel fluorinated bibenzyl anti-androgen, its chemistry and disposition in different animal species. J Pharm Pharmacol. 1981 May;33(5):297-301.

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You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bifluranol 34633-34-6 Endocrinology/Hormones Androgen Receptor BX341 BX 341 BX-341 inhibitor inhibit

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