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Cefozopran hydrochloride

Catalog No. T4984   CAS 113981-44-5
Synonyms: SCE-2787 hydrochloride

Cefozopran hydrochloride (SCE-2787 hydrochloride) is a fourth-generation cephalosporin. is a cell wall biosynthesis inhibitor with a broad spectrum of activity against Gram-positive and Gram-negative bacteria.

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Cefozopran hydrochloride Chemical Structure
Cefozopran hydrochloride, CAS 113981-44-5
Pack Size Availability Price/USD Quantity
2 mg 5 days $ 30.00
5 mg 5 days $ 44.00
1 mL * 10 mM (in DMSO) 5 days $ 54.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Cefozopran hydrochloride (SCE-2787 hydrochloride) is a fourth-generation cephalosporin. is a cell wall biosynthesis inhibitor with a broad spectrum of activity against Gram-positive and Gram-negative bacteria.
In vitro Cefozopran hydrochloride (SCE-2787 hydrochloride), a fourth-generation cephalosporin, exhibits substantial activity against a range of bacteria. Cefozopran hydrochloride is effective against gram-positive organisms, including methicillin-susceptible staphylococci, enterococci, and viridans group streptococci. Additionally, Cefozopran hydrochloride demonstrates efficacy against gram-negative organisms such as Hemophilus influenza. Notably, Cefozopran hydrochloride displays comparatively good activity against enterococci and P. aeruginosa, which are typically resistant to other cephalosporins[2].
In vivo In four-week-old ICR male mice, Cefozopran hydrochloride, administered subcutaneously at doses ranging from 5 to 80 mg/kg twice a day for 5 days, proves effective against acute respiratory tract infections caused by Kiebsiella pneumonia DT-S. In a model of chronic respiratory tract infection induced by K. pneumoniae 27, Cefozopran hydrochloride, at doses between 20 and 80 mg/kg administered subcutaneously twice a day for 7 days in five-week-old CBA/J female mice, exhibits effectiveness comparable to Ceftazidime[2].
Synonyms SCE-2787 hydrochloride
Molecular Weight 551.99
Formula C19H18ClN9O5S2
CAS No. 113981-44-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 30 mg/mL (54.35 mM), sonification is recommended.

DMSO: 30 mg/mL (54.35 mM), sonification is recommended.

TargetMolReferences and Literature

1. Iizawa Y, et al. Therapeutic effect of cefozopran (SCE-2787), a new parenteral cephalosporin, against experimental infections in mice. Antimicrob Agents Chemother. 1993;37(1):100-105. 2. Sato T, et al. A prospective, randomized study comparing cefozopran with piperacillin-tazobactam plus ceftazidime as empirical therapy for febrile neutropenia in children with hematological disorders. Pediatr Blood Cancer. 2008;51(6):774-777.

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Keywords

Cefozopran hydrochloride 113981-44-5 Microbiology/Virology Antifungal Cefozopran Hydrochloride SCE2787 Hydrochloride SCE-2787 Hydrochloride SCE-2787 hydrochloride SCE 2787 Hydrochloride inhibitor inhibit

 

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