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DT-061

Catalog No. T10060LCas No. 1809427-19-7

DT-061, an orally bioavailable protein phosphatase 2A (PP2A) activator, may be used in the therapy of KRAS-mutant and MYC-driven tumorigenesis.

DT-061

DT-061

Catalog No. T10060LCas No. 1809427-19-7
DT-061, an orally bioavailable protein phosphatase 2A (PP2A) activator, may be used in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
Pack SizePriceAvailabilityQuantity
25 mg$1,2308-10 weeks
50 mg$1,6108-10 weeks
100 mg$2,4408-10 weeks
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Product Introduction

Bioactivity
Description
DT-061, an orally bioavailable protein phosphatase 2A (PP2A) activator, may be used in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
In vivo
DT-061 combined with AZD6244 is more significantly efficient. DT-061 (5 mg/kg, oral gavage, 4 weeks) displays single-agent activity in inhibiting H358 or H441 xenograft growth.
Chemical Properties
Molecular Weight520.52
FormulaC25H23F3N2O5S
Cas No.1809427-19-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 125 mg/mL (240.14 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9212 mL9.6058 mL19.2116 mL96.0578 mL
5 mM0.3842 mL1.9212 mL3.8423 mL19.2116 mL
10 mM0.1921 mL0.9606 mL1.9212 mL9.6058 mL
20 mM0.0961 mL0.4803 mL0.9606 mL4.8029 mL
50 mM0.0384 mL0.1921 mL0.3842 mL1.9212 mL
100 mM0.0192 mL0.0961 mL0.1921 mL0.9606 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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