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GSK-J1 lithium salt
Catalog No. T11475Cas No. 2309668-29-7
GSK-J1 lithium salt is an effective inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with an IC 50 of 60 nM for KDM6B.
GSK-J1 lithium salt
Catalog No. T11475Cas No. 2309668-29-7
GSK-J1 lithium salt is an effective inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with an IC 50 of 60 nM for KDM6B.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | |
| 100 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | GSK-J1 lithium salt is an effective inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with an IC 50 of 60 nM for KDM6B. |
| Targets&IC50 | JMJD3 (KDM6B):60 nM |
| In vitro | GSK-J1 selectively targets and binds to the endogenous JMJD3 within the KDM6 subfamily of H3K27 demethylases, effectively inhibiting TNF-α production in human primary macrophages through an H3K27-dependent process [1]. Additionally, it demonstrates an 8.5-fold higher inhibitory potency against KDM5C's demethylase activity compared to KDM5B when assessed at 1 mM α-ketoglutarate, with respective IC50 values of 11 μM and 94 μM [3]. |
| Molecular Weight | 395.38 |
| Formula | C22H22LiN5O2 |
| Cas No. | 2309668-29-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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