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GSK9311

GSK9311
GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively). GSK9311 is a less active analog of GSK6853. It can be used as a negative control.
Catalog No. T13715LCas No. 1923851-49-3

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GSK9311

Catalog No. T13715LCas No. 1923851-49-3

GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively). GSK9311 is a less active analog of GSK6853. It can be used as a negative control.
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2 mg$1085 days
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Product Introduction

Bioactivity
Description
GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively). GSK9311 is a less active analog of GSK6853. It can be used as a negative control.
Targets&IC50
BRPF1:6.0 (pic50), BRPF2:4.3 (pic50)
In vitro
GSK6853 is a less active analogue of GSK6853 in which the 5-amide is alkylated. GSK6853 is a potent (300 pM), soluble, cell active (20 nM), and highly selective inhibitor of the BRPF1 bromodomain. GSK6853 shows properties suitable for cellular and in vivo studies[1].
Chemical Properties
Molecular Weight437.53
FormulaC24H31N5O3
Cas No.1923851-49-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (68.57 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2856 mL11.4278 mL22.8556 mL114.2779 mL
5 mM0.4571 mL2.2856 mL4.5711 mL22.8556 mL
10 mM0.2286 mL1.1428 mL2.2856 mL11.4278 mL
20 mM0.1143 mL0.5714 mL1.1428 mL5.7139 mL
50 mM0.0457 mL0.2286 mL0.4571 mL2.2856 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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