Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HS38 is a specific and ATP-competitive DAPK inhibitor with Kds of 300 nM, 200 nM, and 280 nM for DAPK1, PIM3, and ZIPK. HS38 can be used in studies about smooth muscle-related disorders.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 47.00 | |
10 mg | In stock | $ 67.00 | |
25 mg | In stock | $ 138.00 | |
50 mg | In stock | $ 222.00 | |
100 mg | In stock | $ 361.00 | |
200 mg | In stock | $ 538.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 52.00 |
Description | HS38 is a specific and ATP-competitive DAPK inhibitor with Kds of 300 nM, 200 nM, and 280 nM for DAPK1, PIM3, and ZIPK. HS38 can be used in studies about smooth muscle-related disorders. |
Targets&IC50 | DAPK2:79 nM (Kd), ZIPK:280 nM (Kd), Pim3:200 nM (Kd), DAPK1:300 nM (Kd), DAPK1:IC50 : 200 nM |
In vitro | HS38 shows a Kd of 79 nM for DAPK2. In human aortic SM cells, HS38 reduces relative RLC20 phosphorylation in both the basal and S1P-activated states. In Ca2+-sensitized rabbit ileum, HS38 reduces the contractile force, MYPT1 phosphorylation, and RLC20 phosphorylation[1]. |
Synonyms | HS 38, HS-38 |
Molecular Weight | 349.8 |
Formula | C14H12ClN5O2S |
CAS No. | 1030203-81-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6.4 mg/mL (18.4 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
HS38 1030203-81-6 Apoptosis DAPK HS 38 HS-38 inhibitor inhibit