Halofenozide is an ecdysteroid agonist and used as a pesticide.

The extremely slow excretion of the product in Colorado potato beetle (CPB) suggested that this fact must contribute to the prolonged action of halofenozide on fecundity at its highest dose of 20 μg per adult. Retention of halofenozide in the reproductive system of males of AMF and CPB was low, whereas high levels of radioactivity were recovered in females (ovaries + eggs) [1]. Topical application of 5 μg of the non-steroidal ecdysone agonist RH-0345 (halofenozide) in 0.1 μl DMSO to the primary reproductives during the 2000 season resulted in a significant reduction in the number of eggs laid. There was however complete recovery of the treated females In 2001 both topical application as well as feeding methods were tried. Significant effects were observed only in the topical treatment group, perhaps because of inconsistency in feeding. In this group, total progeny, the number of ovarioles in ovaries and the size of the female's corpora allata (CA) were all significantly reduced [2].