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Heparan Sulfate

Catalog No. T19355   CAS 9050-30-0

Heparan Sulfate is a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

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Heparan Sulfate Chemical Structure
Heparan Sulfate, CAS 9050-30-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 44.00
5 mg In stock $ 97.00
10 mg In stock $ 163.00
25 mg In stock $ 322.00
50 mg In stock $ 538.00
100 mg In stock $ 777.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Heparan Sulfate is a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.
In vitro Heparan sulfate interacts with numerous proteins, including growth factors, morphogens, and adhesion molecules, and thereby regulates important developmental processes in invertebrates and vertebrates. Heparan sulfate chains regulate developmental signaling by acting as co-factors through a variety of mechanisms that include but are not limited to the maintenance of morphogen gradients and co-receptor functions [1]. Heparan sulfate proteoglycans can act as receptors for proteases and protease inhibitors regulating their spatial distribution and activity. Membrane Heparan sulfate proteoglycans act as coreceptors for various tyrosine kinase-type growth factor receptors, lowering their activation threshold or changing the duration of signaling reactions [2]. Heparan sulfate influences the binding affinity of intestinal epithelium cells to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating the regeneration of small intestinal crypts after epithelial injury [3].
In vivo FGF-2/FGFR system is involved in the regulation of astrocytic reactivity and/or proliferation in the brain and its action is potentiated by heparan sulfate [5]. Digestion of heparan sulfate impairs context discrimination in a fear conditioning paradigm and oscillatory network activity in the low theta band after fear conditioning. Thus, heparan sulfate maintains neuronal excitability and, as a consequence, support synaptic plasticity and learning [4].
Molecular Weight 593.47(monomer)
Formula C12H19NO20S3 (monomer)
CAS No. 9050-30-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 100 mg/mL, sonification is recommended.

TargetMolReferences and Literature

1. Kraushaar DC, et al. Heparan sulfate: a key regulator of embryonic stem cell fate. Biol Chem. 2013 Jun;394(6):741-51. 2. Sarrazin S, et al. Heparan sulfate proteoglycans. Cold Spring Harb Perspect Biol. 2011 Jul 1;3(7). pii: a004952. 3. Yamamoto S, et al. Heparan sulfate on intestinal epithelial cells plays a critical role in intestinal crypt homeostasis via Wnt/β-catenin signaling. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 1;305(3):G241-9. 4. Minge D, et al. Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination. Cereb Cortex. 2017 Feb 1;27(2):903-918. 5. Gómez-Pinilla F, et al. Regulation of astrocyte proliferation by FGF-2 and heparan sulfate in vivo. J Neurosci. 1995 Mar;15(3 Pt 1):2021-9.

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Keywords

Heparan Sulfate 9050-30-0 Angiogenesis Cytoskeletal Signaling Metabolism Stem Cells Tyrosine Kinase/Adaptors Endogenous Metabolite FGFR Wnt/beta-catenin Fibroblast growth factor receptor Wnt Inhibitor Heparan inhibit inhibitor

 

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