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JZP-361

Catalog No. T27703Cas No. 1680193-80-9
Alias JZP361, JZP 361

JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 displays anti-histaminergic activities. JZP-361 can be used in studies about asthma.

JZP-361

JZP-361

Purity: 99.41%
Catalog No. T27703Alias JZP361, JZP 361Cas No. 1680193-80-9
JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 displays anti-histaminergic activities. JZP-361 can be used in studies about asthma.
Pack SizePriceAvailabilityQuantity
5 mg$38In Stock
10 mg$59In Stock
25 mg$118In Stock
50 mg$197In Stock
100 mg$296In Stock
200 mg$419In Stock
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Purity:99.41%
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Product Introduction

Bioactivity
Description
JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 displays anti-histaminergic activities. JZP-361 can be used in studies about asthma.
Targets&IC50
ABHD6 (human):1.79 μM, FAAH (human):7.24 μM, MAGL (human):46 nM, H1 receptor:6.81 (pA2)
In vitro
JZP-361 shows the affinity of H1 antagonistic with a pA2 of 6.81). JZP-361(≤10 μM) does not show cannabinoid receptor activity. JZP-361 displays favorable interactions within the important hydrogen-bonding of the carbonyl oxygen to the oxyanion hole[1].
AliasJZP361, JZP 361
Chemical Properties
Molecular Weight405.88
FormulaC22H20ClN5O
Cas No.1680193-80-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 36.5 mg/mL (90.0 mM)
DMSO: 1 mg/ml, Sonication is recommended.
Solution Preparation Table
Ethanol
1mg5mg10mg50mg
1 mM2.4638 mL12.3189 mL24.6378 mL123.1891 mL
5 mM0.4928 mL2.4638 mL4.9276 mL24.6378 mL
10 mM0.2464 mL1.2319 mL2.4638 mL12.3189 mL
20 mM0.1232 mL0.6159 mL1.2319 mL6.1595 mL
50 mM0.0493 mL0.2464 mL0.4928 mL2.4638 mL

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