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JZP-361

Catalog No. T27703 CAS 1680193-80-9

Synonyms: JZP361, JZP 361

JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 displays anti-histaminergic activities. JZP-361 can be used in studies about asthma.

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JZP-361, CAS 1680193-80-9

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Purity: 98%

Biological Description

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Description	JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 displays anti-histaminergic activities. JZP-361 can be used in studies about asthma.
Targets&IC50	H1 Receptor:6.81 (pA2), hMAGL:46 nM, hABHD6:1.79 μM, hFAAH:7.24 μM
In vitro	JZP-361 shows the affinity of H1 antagonistic with a pA2 of 6.81). JZP-361(≤10 μM) does not show cannabinoid receptor activity. JZP-361 displays favorable interactions within the important hydrogen-bonding of the carbonyl oxygen to the oxyanion hole[1].

Synonyms	JZP361, JZP 361
Molecular Weight	405.88
Formula	C22H20ClN5O
CAS No.	1680193-80-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 36.5 mg/mL (90.0 mM)

DMSO: 7.3 mg/mL (18.0 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Jayendra Z Patel, et al. Loratadine analogues as MAGL inhibitors. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1436-42.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JZP-361 1680193-80-9 Metabolism Lipase JZP361 JZP 361 Inhibitor inhibitor inhibit

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