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JZP-361

JZP-361
JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 displays anti-histaminergic activities. JZP-361 can be used in studies about asthma.
Catalog No. T27703Cas No. 1680193-80-9
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Purity:99.41%
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JZP-361

Purity: 99.41%
Catalog No. T27703Alias JZP361, JZP 361Cas No. 1680193-80-9

JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 displays anti-histaminergic activities. JZP-361 can be used in studies about asthma.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$38In Stock
10 mg$59In Stock
25 mg$118In Stock
50 mg$197In Stock
100 mg$296In Stock
200 mg$419In Stock
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Product Introduction

Bioactivity
Description
JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 displays anti-histaminergic activities. JZP-361 can be used in studies about asthma.
Targets&IC50
FAAH (human):7.24 μM, ABHD6 (human):1.79 μM, H1 receptor:6.81 (pA2), MAGL (human):46 nM
In vitro
JZP-361 shows the affinity of H1 antagonistic with a pA2 of 6.81). JZP-361(≤10 μM) does not show cannabinoid receptor activity. JZP-361 displays favorable interactions within the important hydrogen-bonding of the carbonyl oxygen to the oxyanion hole[1].
AliasJZP361, JZP 361
Chemical Properties
Molecular Weight405.88
FormulaC22H20ClN5O
Cas No.1680193-80-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 36.5 mg/mL (90.0 mM)
DMSO: 1 mg/ml, Sonication is recommended.
Solution Preparation Table
Ethanol
1mg5mg10mg50mg
1 mM2.4638 mL12.3189 mL24.6378 mL123.1891 mL
5 mM0.4928 mL2.4638 mL4.9276 mL24.6378 mL
10 mM0.2464 mL1.2319 mL2.4638 mL12.3189 mL
20 mM0.1232 mL0.6159 mL1.2319 mL6.1595 mL
50 mM0.0493 mL0.2464 mL0.4928 mL2.4638 mL

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