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JZP-361

Catalog No. T27703 CAS 1680193-80-9

Synonyms: JZP361, JZP 361

JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 displays anti-histaminergic activities. JZP-361 can be used in studies about asthma.

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JZP-361, CAS 1680193-80-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 64.00
10 mg	In stock	$ 98.00
25 mg	In stock	$ 197.00
50 mg	In stock	$ 328.00
100 mg	In stock	$ 493.00
500 mg	In stock	$ 1,070.00
1 mL * 10 mM (in DMSO)	In stock	$ 70.00

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Purity: 99.41%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 displays anti-histaminergic activities. JZP-361 can be used in studies about asthma.
Targets&IC50	FAAH (human):7.24 μM, ABHD6 (human):1.79 μM, MAGL (human):46 nM, H1 receptor:6.81 (pA2)
In vitro	JZP-361 shows the affinity of H1 antagonistic with a pA2 of 6.81). JZP-361(≤10 μM) does not show cannabinoid receptor activity. JZP-361 displays favorable interactions within the important hydrogen-bonding of the carbonyl oxygen to the oxyanion hole[1].

Synonyms	JZP361, JZP 361
Molecular Weight	405.88
Formula	C22H20ClN5O
CAS No.	1680193-80-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 36.5 mg/mL (90.0 mM)

DMSO: 7.3 mg/mL (18.0 mM)

References and Literature

1. Jayendra Z Patel, et al. Loratadine analogues as MAGL inhibitors. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1436-42.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

MJN110 ABX-1431 Atglistatin Y-320 WWL70 PF-06795071 Endothelial lipase inhibitor-1 Beta-Sitosterol

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JZP-361 1680193-80-9 Metabolism Lipase JZP361 JZP 361 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.