store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KDM5A-IN-1 is an orally available, potent and selective inhibitor of the pan-histidine lysine demethylase 5 KDM5, inhibiting KDM5A, KDM5B, and KDM5C with IC50 values of 45 nM, 56 nM, and 55 nM, respectively.KDM5A-IN-1 inhibits PC9 H3K4Me3, and may be useful in cancer research.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 289.00 | |
25 mg | 6-8 weeks | $ 954.00 | |
50 mg | 6-8 weeks | $ 1,240.00 | |
100 mg | 6-8 weeks | $ 1,740.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 396.00 |
Description | KDM5A-IN-1 is an orally available, potent and selective inhibitor of the pan-histidine lysine demethylase 5 KDM5, inhibiting KDM5A, KDM5B, and KDM5C with IC50 values of 45 nM, 56 nM, and 55 nM, respectively.KDM5A-IN-1 inhibits PC9 H3K4Me3, and may be useful in cancer research. |
Targets&IC50 | KDM5A:45 nM, KDM5B:56 nM, KDM5C:55 nM |
In vivo | KDM5A-IN-1 (compound 50, 5 mg/kg; oral administration; female CD-1 mice) exhibits moderate clearance in mice (28 mL/min/kg), good oral bioavailability (F% 34), significantly low plasma protein binding in mice (40%), and a half-life (t1/2) of 0.4 hours[1]. |
Molecular Weight | 290.36 |
Formula | C15H22N4O2 |
CAS No. | 1905481-36-8 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (103.32 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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KDM5A-IN-1 1905481-36-8 Chromatin/Epigenetic Histone Demethylase KDM-5A-IN-1 KDM5AIN1 KDM5A IN 1 inhibitor inhibit