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KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. KL001 thus provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $32 | In Stock | |
5 mg | $80 | In Stock | |
10 mg | $116 | In Stock | |
25 mg | $198 | In Stock | |
50 mg | $293 | In Stock | |
100 mg | $438 | In Stock | |
500 mg | $983 | In Stock | |
1 mL x 10 mM (in DMSO) | $89 | In Stock |
Description | KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. KL001 thus provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes. |
Alias | KL-001, KL 001 |
Molecular Weight | 398.48 |
Formula | C21H22N2O4S |
Cas No. | 309928-48-1 |
Smiles | CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)Cc1ccco1 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 65 mg/ml (163.12 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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