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KL001

Catalog No. T22891Cas No. 309928-48-1
Alias KL-001, KL 001

KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. KL001 thus provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes.

KL001

KL001

Purity: 98.85%
Catalog No. T22891Alias KL-001, KL 001Cas No. 309928-48-1
KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. KL001 thus provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes.
Pack SizePriceAvailabilityQuantity
1 mg$32In Stock
5 mg$80In Stock
10 mg$116In Stock
25 mg$198In Stock
50 mg$293In Stock
100 mg$438In Stock
500 mg$983In Stock
1 mL x 10 mM (in DMSO)$89In Stock
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Purity:98.85%
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Product Introduction

Bioactivity
Description
KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. KL001 thus provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes.
AliasKL-001, KL 001
Chemical Properties
Molecular Weight398.48
FormulaC21H22N2O4S
Cas No.309928-48-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 65 mg/ml (163.12 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5095 mL12.5477 mL25.0954 mL125.4768 mL
5 mM0.5019 mL2.5095 mL5.0191 mL25.0954 mL
10 mM0.2510 mL1.2548 mL2.5095 mL12.5477 mL
20 mM0.1255 mL0.6274 mL1.2548 mL6.2738 mL
50 mM0.0502 mL0.2510 mL0.5019 mL2.5095 mL
100 mM0.0251 mL0.1255 mL0.2510 mL1.2548 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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