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KZR-504
Catalog No. T15678Cas No. 1629052-78-3
KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).
KZR-504
Catalog No. T15678Cas No. 1629052-78-3
KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $1,185 | 2-4 weeks | |
| 5 mg | $2,608 | 2-4 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively). |
| Targets&IC50 | LMP2:51 nM, LMP7:4.274 μM |
| In vivo | Assessment of LMP2 inhibition, along with antitargets LMP7 and β5, in mouse tissues indicates that KZR-504 is both selective and potent in vivo. In all tested tissues, except the brain, it achieves over 50% target inhibition at doses exceeding 1 mg/kg [1]. |
| Molecular Weight | 413.42 |
| Formula | C21H23N3O6 |
| Cas No. | 1629052-78-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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