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MP07-66

MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.

Catalog No. T9744Cas No. 1938056-90-6

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Purity:97.83%

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COA HPLC HNMR

MP07-66

Catalog No. T9744Cas No. 1938056-90-6

MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.

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Pack Size	Price	Availability
1 mg	$38	In Stock
5 mg	$98	In Stock
10 mg	$158	In Stock
25 mg	$287	In Stock
50 mg	$417	In Stock
100 mg	$575	In Stock
200 mg	$779	In Stock
1 mL x 10 mM (in DMSO)	$107	In Stock

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Product Introduction

Bioactivity

Description

MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.

In vitro

CLL cells were incubated with increasing concentrations of MP07-66 (0-16 μM) for 24 and 48 hours and then subject to annexin V–PI flow cytometry. The level of apoptosis reached 50% and 80%, at 24 hours and 48 hours, respectively, at a MP07-66 concentration as high as 16 μM, which paralleled PARP cleavage, a marker of caspase-dependent apoptosis. In addition, the phosphorylation status of PP2A targets, namely Akt, GSK-3, and SHP-1, was negatively affected by the treatment with MP07-66, triggering known downstream events promoting apoptosis, such as Mcl-1 degradation and caspase-3 activation[1].

Chemical Properties

Molecular Weight	323.47
Formula	C₁₉H₃₃NO₃
Cas No.	1938056-90-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 250 mg/mL (772.87 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0915 mL	15.4574 mL	30.9148 mL	154.5738 mL
5 mM	0.6183 mL	3.0915 mL	6.1830 mL	30.9148 mL
10 mM	0.3091 mL	1.5457 mL	3.0915 mL	15.4574 mL
20 mM	0.1546 mL	0.7729 mL	1.5457 mL	7.7287 mL
50 mM	0.0618 mL	0.3091 mL	0.6183 mL	3.0915 mL
100 mM	0.0309 mL	0.1546 mL	0.3091 mL	1.5457 mL

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