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N-Bis(2-hydroxypropyl)nitrosamine

Catalog No. T19445Cas No. 53609-64-6
Alias Diisopropanolnitrosamine, Di(2-hydroxypropyl)nitrosamine, DHPN

N-Bis(2-hydroxypropyl)nitrosamine (DHPN) is a carcinogenic agent.

N-Bis(2-hydroxypropyl)nitrosamine

N-Bis(2-hydroxypropyl)nitrosamine

Catalog No. T19445Alias Diisopropanolnitrosamine, Di(2-hydroxypropyl)nitrosamine, DHPNCas No. 53609-64-6
N-Bis(2-hydroxypropyl)nitrosamine (DHPN) is a carcinogenic agent.
Pack SizePriceAvailabilityQuantity
25 mg$44In Stock
50 mg$53In Stock
100 mg$83In Stock
200 mg$119In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Purity:≥98%
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Product Introduction

Bioactivity
Description
N-Bis(2-hydroxypropyl)nitrosamine (DHPN) is a carcinogenic agent.
In vivo
The carcinogenic activity of orally administered N-bis(2-hydroxypropyl)-nitrosamine (DHPN) in male Wistar rats was evaluated with respect to its dose. DHPN was administered at two doses, 100 ppm and 500 ppm, in the drinking water to rats for 25 to 52 weeks. Tumors developed in the lung, liver, and thyroid of rats receiving 100 ppm DHPN and in the lung, liver thyroid, esophagus, kidney, and urinary bladder of rats receiving 500 ppm DHPN. The principal target organ was the lung in rats receiving either 100 or 500 ppm DHPN, indicating that the carcinogenic action of these doses of DHPN was similar to that of higher doses previously reported[2].
AliasDiisopropanolnitrosamine, Di(2-hydroxypropyl)nitrosamine, DHPN
Chemical Properties
Molecular Weight162.19
FormulaC6H14N2O3
Cas No.53609-64-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (616.56 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM6.1656 mL30.8280 mL61.6561 mL308.2804 mL
5 mM1.2331 mL6.1656 mL12.3312 mL61.6561 mL
10 mM0.6166 mL3.0828 mL6.1656 mL30.8280 mL
20 mM0.3083 mL1.5414 mL3.0828 mL15.4140 mL
50 mM0.1233 mL0.6166 mL1.2331 mL6.1656 mL
100 mM0.0617 mL0.3083 mL0.6166 mL3.0828 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

inhibitNBis(2hydroxypropyl)nitrosamineN Bis(2 hydroxypropyl)nitrosamineInhibitorN-Bis(2-hydroxypropyl)nitrosamine
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