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N-Boc-N-bis(PEG4-acid)

Catalog No. T18395Cas No. 2093152-88-4

N-Boc-N-bis(PEG4-acid) is a PEG-based linker for PROTACs [Proteolysis Targeting Chimeras] that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

N-Boc-N-bis(PEG4-acid)

N-Boc-N-bis(PEG4-acid)

Catalog No. T18395Cas No. 2093152-88-4
N-Boc-N-bis(PEG4-acid) is a PEG-based linker for PROTACs [Proteolysis Targeting Chimeras] that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.
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2 mg$395 days
5 mg$605 days
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Product Introduction

Bioactivity
Description
N-Boc-N-bis(PEG4-acid) is a PEG-based linker for PROTACs [Proteolysis Targeting Chimeras] that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.
In vitro
PROTACs consist of two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other binds to the target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Chemical Properties
Molecular Weight613.69
FormulaC27H51NO14
Cas No.2093152-88-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

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