Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naproxen. It is hydrolyzed to pharmacologically active Naproxen once absorbed.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 854.00 | |
50 mg | 6-8 weeks | $ 1,110.00 | |
100 mg | 6-8 weeks | $ 1,610.00 | |
1 mL * 10 mM (in DMSO) | 6-8 weeks | $ 259.00 |
Description | Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naproxen. It is hydrolyzed to pharmacologically active Naproxen once absorbed. |
Targets&IC50 | COX-2:5.15 μM, COX-1:8.72 μM |
In vitro | Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is an approximately equipotent inhibitor of COX-1 and COX-2 in intact cells (IC50s: 2.2 μg/mL and 1.3 μg/mL, respectively)[1]. |
In vivo | Naproxen is shown to inhibit the time-courses of pain, fever, and PGE2 with similar potencies (IC50=27, 40, 13 μM). Naproxen exerts an anti-inflammatory and antifibrotic effect in the mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation [2][3]. |
Synonyms | LT-NS 001, MX 1094 |
Molecular Weight | 336.4 |
Formula | C17H20O5S |
CAS No. | 385800-16-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Naproxen etemesil 385800-16-8 Metabolism PDE MX-1094 LT-NS001 LT-NS 001 LT-NS-001 MX1094 MX 1094 inhibitor inhibit