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Naproxen etemesil
Catalog No. T16272Cas No. 385800-16-8
Alias MX 1094, LT-NS 001
Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naproxen. It is hydrolyzed to pharmacologically active Naproxen once absorbed.
Naproxen etemesil
Catalog No. T16272Alias MX 1094, LT-NS 001Cas No. 385800-16-8
Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naproxen. It is hydrolyzed to pharmacologically active Naproxen once absorbed.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $854 | 6-8 weeks | |
| 50 mg | $1,110 | 6-8 weeks | |
| 100 mg | $1,610 | 6-8 weeks | |
| 1 mL x 10 mM (in DMSO) | $259 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naproxen. It is hydrolyzed to pharmacologically active Naproxen once absorbed. |
| Targets&IC50 | COX-2:5.15 μM, COX-1:8.72 μM |
| In vitro | Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is an approximately equipotent inhibitor of COX-1 and COX-2 in intact cells (IC50s: 2.2 μg/mL and 1.3 μg/mL, respectively)[1]. |
| In vivo | Naproxen is shown to inhibit the time-courses of pain, fever, and PGE2 with similar potencies (IC50=27, 40, 13 μM). Naproxen exerts an anti-inflammatory and antifibrotic effect in the mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation [2][3]. |
| Alias | MX 1094, LT-NS 001 |
| Molecular Weight | 336.4 |
| Formula | C17H20O5S |
| Cas No. | 385800-16-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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