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OSMI-4

Catalog No. T12328Cas No. 2260791-14-6

OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor (EC50 of 3 μM in cells) that can be used to study OGT inhibition in different human cell lines.

OSMI-4

OSMI-4

Purity: 99.28%
Catalog No. T12328Cas No. 2260791-14-6
OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor (EC50 of 3 μM in cells) that can be used to study OGT inhibition in different human cell lines.
Pack SizePriceAvailabilityQuantity
1 mg$215In Stock
5 mg$538In Stock
10 mg$778In Stock
25 mg$1,430In Stock
50 mg$2,450In Stock
100 mg$3,280In Stock
500 mg$4,360In Stock
1 mL x 10 mM (in DMSO)$593In Stock
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Purity:99.28%
ee:100%
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Product Introduction

Bioactivity
Description
OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor (EC50 of 3 μM in cells) that can be used to study OGT inhibition in different human cell lines.
Targets&IC50
OGT:3 μM (EC50)
In vitro
METHODS: HEK293T cells were treated with OSMI-4 (10 μM, 2 hours) and quantitative PCR was performed using primers for the OGT retained intron (intron 4) and spliced ​​exon (exon 4).
RESULTS The bar graph shows that OSMI-4 increases retained intron splicing. [1]
METHODS: HEK293T cells were treated with OSMI-4 (20, 50 μM, 24 hours); HEK293T cells were treated with OSMI-4 (0.1, 1, 5, 5, 10, 20 μM, 2, 24, 48 hours); Western blot analysis of total O-GlcNAc was performed.
RESULTS O-GlcNAc levels were reduced to a greater extent following OSMI-4 treatment; 24 hours of OSMI-4 treatment of HEK293T cells resulted in a dose-dependent decrease in O-GlcNAc levels, with effects seen with only 5 µM of compound treatment, and these effects could be observed in as little as 2 hours or 48 hours. [1]
Chemical Properties
Molecular Weight604.09
FormulaC27H26ClN3O7S2
Cas No.2260791-14-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (74.49 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6554 mL8.2769 mL16.5538 mL82.7691 mL
5 mM0.3311 mL1.6554 mL3.3108 mL16.5538 mL
10 mM0.1655 mL0.8277 mL1.6554 mL8.2769 mL
20 mM0.0828 mL0.4138 mL0.8277 mL4.1385 mL
50 mM0.0331 mL0.1655 mL0.3311 mL1.6554 mL

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