Shopping Cart
- Remove All
- Your shopping cart is currently empty
OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor (EC50 of 3 μM in cells) that can be used to study OGT inhibition in different human cell lines.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $215 | In Stock | |
5 mg | $538 | In Stock | |
10 mg | $778 | In Stock | |
25 mg | $1,430 | In Stock | |
50 mg | $2,450 | In Stock | |
100 mg | $3,280 | In Stock | |
500 mg | $4,360 | In Stock | |
1 mL x 10 mM (in DMSO) | $593 | In Stock |
Description | OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor (EC50 of 3 μM in cells) that can be used to study OGT inhibition in different human cell lines. |
Targets&IC50 | OGT:3 μM (EC50) |
In vitro | METHODS: HEK293T cells were treated with OSMI-4 (10 μM, 2 hours) and quantitative PCR was performed using primers for the OGT retained intron (intron 4) and spliced exon (exon 4). RESULTS The bar graph shows that OSMI-4 increases retained intron splicing. [1] METHODS: HEK293T cells were treated with OSMI-4 (20, 50 μM, 24 hours); HEK293T cells were treated with OSMI-4 (0.1, 1, 5, 5, 10, 20 μM, 2, 24, 48 hours); Western blot analysis of total O-GlcNAc was performed. RESULTS O-GlcNAc levels were reduced to a greater extent following OSMI-4 treatment; 24 hours of OSMI-4 treatment of HEK293T cells resulted in a dose-dependent decrease in O-GlcNAc levels, with effects seen with only 5 µM of compound treatment, and these effects could be observed in as little as 2 hours or 48 hours. [1] |
Molecular Weight | 604.09 |
Formula | C27H26ClN3O7S2 |
Cas No. | 2260791-14-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (74.49 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.