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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $61 | In Stock | |
5 mg | $142 | In Stock | |
10 mg | $213 | In Stock | |
25 mg | $438 | In Stock | |
50 mg | $687 | In Stock | |
100 mg | $987 | In Stock | |
500 mg | $1,970 | In Stock | |
1 mL x 10 mM (in DMSO) | $156 | In Stock |
Description | Ozanimod hydrochloride (RPC-1063 hydrochloride) is an orally available, selective and potent sphingosine 1-phosphate (S1P) receptor modulator that shows high affinity for S1P1 and S1P5.Ozanimod has potential anticancer activity and can be used in the study of multiple sclerosis (MS), ulcerative multiple sclerosis (UMS), and other diseases. (MS), ulcerative colitis, coronavirus infections and myelodysplasia. |
Targets&IC50 | S1PR1:1.03 nM (EC50), S1PR5:8.6 nM (EC50) |
In vitro | Ozanimod hydrochloride, as a sphingosine-1-phosphate (S1P) receptor modulator, selectively binds with high affinity to S1P receptor subtypes 1 (S1P1) and S1P5[1]. |
In vivo | In the experimental autoimmune encephalomyelitis (EAE) model, Ozanimod hydrochloride (0.05, 0.2, or 1 mg/kg; oral gavage; once daily; for 14 consecutive days) alleviated weight loss, with significantly reduced terminal disease scores observed in the 0.2 and 1 mg/kg dose groups. Moreover, cell counts were significantly reduced in all dose groups[1]. |
Alias | BMS-986374 hydrochloride, RPC-1063 hydrochloride |
Molecular Weight | 440.92 |
Formula | C23H25ClN4O3 |
Cas No. | 1618636-37-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 150 mg/mL (340.20 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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