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Ozanimod hydrochloride

Ozanimod hydrochloride
Ozanimod hydrochloride (RPC-1063 hydrochloride) is an orally available, selective and potent sphingosine 1-phosphate (S1P) receptor modulator that shows high affinity for S1P1 and S1P5.Ozanimod has potential anticancer activity and can be used in the study of multiple sclerosis (MS), ulcerative multiple sclerosis (UMS), and other diseases. (MS), ulcerative colitis, coronavirus infections and myelodysplasia.
Catalog No. T62552Cas No. 1618636-37-5
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Purity:99.81%
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Ozanimod hydrochloride

Catalog No. T62552Alias BMS-986374 hydrochloride, RPC-1063 hydrochlorideCas No. 1618636-37-5

Ozanimod hydrochloride (RPC-1063 hydrochloride) is an orally available, selective and potent sphingosine 1-phosphate (S1P) receptor modulator that shows high affinity for S1P1 and S1P5.Ozanimod has potential anticancer activity and can be used in the study of multiple sclerosis (MS), ulcerative multiple sclerosis (UMS), and other diseases. (MS), ulcerative colitis, coronavirus infections and myelodysplasia.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$61In Stock
5 mg$142In Stock
10 mg$213In Stock
25 mg$438In Stock
50 mg$687In Stock
100 mg$987In Stock
500 mg$1,970In Stock
1 mL x 10 mM (in DMSO)$156In Stock
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Product Introduction

Bioactivity
Description
Ozanimod hydrochloride (RPC-1063 hydrochloride) is an orally available, selective and potent sphingosine 1-phosphate (S1P) receptor modulator that shows high affinity for S1P1 and S1P5.Ozanimod has potential anticancer activity and can be used in the study of multiple sclerosis (MS), ulcerative multiple sclerosis (UMS), and other diseases. (MS), ulcerative colitis, coronavirus infections and myelodysplasia.
Targets&IC50
S1PR1:1.03 nM (EC50), S1PR5:8.6 nM (EC50)
In vitro
Ozanimod hydrochloride, as a sphingosine-1-phosphate (S1P) receptor modulator, selectively binds with high affinity to S1P receptor subtypes 1 (S1P1) and S1P5[1].
In vivo
In the experimental autoimmune encephalomyelitis (EAE) model, Ozanimod hydrochloride (0.05, 0.2, or 1 mg/kg; oral gavage; once daily; for 14 consecutive days) alleviated weight loss, with significantly reduced terminal disease scores observed in the 0.2 and 1 mg/kg dose groups. Moreover, cell counts were significantly reduced in all dose groups[1].
AliasBMS-986374 hydrochloride, RPC-1063 hydrochloride
Chemical Properties
Molecular Weight440.92
FormulaC23H25ClN4O3
Cas No.1618636-37-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 150 mg/mL (340.20 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2680 mL11.3399 mL22.6799 mL113.3993 mL
5 mM0.4536 mL2.2680 mL4.5360 mL22.6799 mL
10 mM0.2268 mL1.1340 mL2.2680 mL11.3399 mL
20 mM0.1134 mL0.5670 mL1.1340 mL5.6700 mL
50 mM0.0454 mL0.2268 mL0.4536 mL2.2680 mL
100 mM0.0227 mL0.1134 mL0.2268 mL1.1340 mL

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