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PMX 205 Trifluoroacetate (514814-49-4 free base)

PMX 205 Trifluoroacetate (514814-49-4 free base)
PMX 205 Trifluoroacetate is a potent complement antagonist of C5a receptor.
Catalog No. T12506
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PMX 205 Trifluoroacetate (514814-49-4 free base)

Catalog No. T12506
PMX 205 Trifluoroacetate is a potent complement antagonist of C5a receptor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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1 mg$113Backorder
5 mg$296Backorder
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Product Introduction

Bioactivity
Description
PMX 205 Trifluoroacetate is a potent complement antagonist of C5a receptor.
In vitro
PMX205, which is an antagonist, gave more effects towards the cell as compared with the treatment of EP54.
In vivo
oral delivery of a cyclic hexapeptide C5a receptor antagonist (PMX205) for 2-3 mo resulted in substantial reduction of pathological markers such as fibrillar amyloid deposits (49-62%) and activated glia (42-68%) in two mouse models of AD. The reduction in pathology was correlated with improvements in a passive avoidance behavioral task in Tg2576 mice. In 3xTg mice, PMX205 also significantly reduced hyperphosphorylated tau (69%). These data provide the first evidence that inhibition of a proinflammatory receptor-mediated function of the complement cascade (i.e., C5aR) can interfere with neuroinflammation and neurodegeneration in AD rodent models, suggesting a novel therapeutic target for reducing pathology and improving cognitive function in human AD patients[3].
AliasPMX 205 Trifluoroacetate
Chemical Properties
Molecular Weight953.06
FormulaC47H63F3N10O8
Cas No.
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (104.93 mM)
H2O: 0.67 mg/mL (0.70 mM), Sonication is recommended.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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