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PMX 205 acetate(514814-49-4 free base)

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Purity:99.4%

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COA HPLC MS

PMX 205 acetate(514814-49-4 free base)

Catalog No. T12506L1

PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).

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Pack Size	Price	Availability
1 mg	$113	In Stock
5 mg	$296	In Stock
10 mg	$389	In Stock
25 mg	$827	In Stock
50 mg	$1,320	In Stock
100 mg	$1,928	In Stock
1 mL x 10 mM (in DMSO)	$415	In Stock

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Product Introduction

Bioactivity

Description	PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).
In vitro	PMX 205 (PMX205) group is in between 0.09893 to 0.2465, EP54 group, 0.02724 to 0.1748 and Tamoxifen group, the value recorded in between 0.09880 to 0.2464. For the 48 h plate of incubation time, only two groups of PMX 205 and Tamoxifen show a significant result. The values recorded are in between 0.04987 to 0.3273 and 0.5777 to 0.8551 respectively. For the 72 h plate, only one group shows a significant result, PMX 205 (antagonist group) with the value recorded in between 0.02136 to 0.5322[1].
In vivo	Tg2576 mice are treated with PMX 205 (PMX205) at 20 μg/mL in the drinking water (n=17) from 12 to 15 mo of age, the time frame at which there is a rapid accumulation of amyloid deposits in these animals. Untreated Tg2576 animals (n=11) are used as controls. After 3 mo, animals treated with PMX 205 show significantly less fibrillar plaque load (thioflavine reactivity) than do untreated animals. In 3×Tg mice, PMX 205 also significantly reduces hyperphosphorylated tau (69%)[2].

Chemical Properties

Molecular Weight	899.09
Formula	C47H66N10O8
Cas No.

Storage & Solubility Information

Storage

keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (66.73 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1122 mL	5.5612 mL	11.1224 mL	55.6118 mL
5 mM	0.2224 mL	1.1122 mL	2.2245 mL	11.1224 mL
10 mM	0.1112 mL	0.5561 mL	1.1122 mL	5.5612 mL
20 mM	0.0556 mL	0.2781 mL	0.5561 mL	2.7806 mL
50 mM	0.0222 mL	0.1112 mL	0.2224 mL	1.1122 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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