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ADH-503
🥰Excellent
Catalog No. T7776Cas No. 2055362-74-6
Alias GB1275
ADH-503 (GB1275) is an orally available, allosteric CD11b small molecule agonist that can lead to repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhancement of dendritic cell responses.
ADH-503
🥰Excellent
Purity: 100%
Catalog No. T7776Alias GB1275Cas No. 2055362-74-6
ADH-503 (GB1275) is an orally available, allosteric CD11b small molecule agonist that can lead to repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhancement of dendritic cell responses.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $48 | In Stock | |
| 10 mg | $77 | In Stock | |
| 25 mg | $129 | In Stock | |
| 50 mg | $207 | In Stock | |
| 100 mg | $288 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ADH-503 (GB1275) is an orally available, allosteric CD11b small molecule agonist that can lead to repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhancement of dendritic cell responses. |
| In vitro | METHODS: ADH-503 (GB1275) (4 μM, 10 days) was used to investigate the expression of macrophage markers in two syngeneic orthotopic models. RESULTS After treatment with ADH-503 (GB1275), macrophages expressed higher levels of MHCI, MHCII, CD80, and CD86, indicating improved antigen presentation properties of the remaining macrophages. [1] |
| In vivo | METHODS: ADH-503 (GB1275) (30, 100 mg/kg, oral) was administered to rats and C57/B6 mice to test the pharmacokinetics (PK) and safety. RESULTS The mean half-life of ADH-503 (GB1275) in rats and mice after administration was 4.68 and 3.95 hours, and the Cmax and AUC0-t in plasma were 1716 and 2594 ng/mL and 6950 and 13962 ng.h/mL, respectively. [1] |
| Animal Research | Animal Model:Male rats.Dosage:30,100 mg/kg (Pharmacokinetic Analysis). Administration:Oral gavage twice a day; on days 1 and 5 |
| Alias | GB1275 |
| Molecular Weight | 524.7 |
| Formula | C27H28N2O5S2 |
| Cas No. | 2055362-74-6 |
| Smiles | C[N+](C)(C)CCO.[O-]C(=O)c1ccc(cc1)-c1ccc(\C=C2/SC(=S)N(Cc3ccccc3)C2=O)o1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 5.25 mg/mL (10 mM)  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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