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(Z)-Leukadherin-1
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Catalog No. T13379Cas No. 2055362-72-4
Alias ADH-503 free base
(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b.
(Z)-Leukadherin-1
😃Good
Catalog No. T13379Alias ADH-503 free baseCas No. 2055362-72-4
(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $30 | 5 days | |
| 5 mg | $45 | 5 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | (Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b. |
| In vitro | (Z)-Leukadherin-1 (4 μM) treatment reduces the numbers of total tumor-infiltrating CD11b+ cells and subsets of CD11b+ monocytes, eosinophils, granulocytes, and macrophages. (Z)-Leukadherin-1 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses[1]. |
| In vivo | (Z)-Leukadherin-1 shows a mean half-life of 4.68 and 3.95 h, a maximum concentration of 1716 and 2594 ng/ml and AUC(0-t) in the plasma of 6950 and 13962 ng·h/ml at 30 and 100 mg/kg dosing, respectively. In KPC mice, (Z)-Leukadherin-1 (30, 60, or 120 mg/kg; gavage) delayes tumor progression and leads to a significantly decreased tumor burden in time-point analysis and improved overall survival[1]. |
| Alias | ADH-503 free base |
| Molecular Weight | 421.49 |
| Formula | C22H15NO4S2 |
| Cas No. | 2055362-72-4 |
| Relative Density. | 1.50 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (9.49 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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