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(Z)-Leukadherin-1

Catalog No. T13379Cas No. 2055362-72-4

(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b.

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Pack Size	Price	Availability
2 mg	$30	5 days
5 mg	$45	5 days
1 mL x 10 mM (in DMSO)	$55	5 days

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Product Introduction

Bioactivity

Description	(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b.
In vitro	(Z)-Leukadherin-1 (4 μM) treatment reduces the numbers of total tumor-infiltrating CD11b+ cells and subsets of CD11b+ monocytes, eosinophils, granulocytes, and macrophages. (Z)-Leukadherin-1 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses[1].
In vivo	(Z)-Leukadherin-1 shows a mean half-life of 4.68 and 3.95 h, a maximum concentration of 1716 and 2594 ng/ml and AUC(0-t) in the plasma of 6950 and 13962 ng·h/ml at 30 and 100 mg/kg dosing, respectively. In KPC mice, (Z)-Leukadherin-1 (30, 60, or 120 mg/kg; gavage) delayes tumor progression and leads to a significantly decreased tumor burden in time-point analysis and improved overall survival[1].
Alias	ADH-503 free base

Chemical Properties

Molecular Weight	421.49
Formula	C22H15NO4S2
Cas No.	2055362-72-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4 mg/mL (9.49 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3725 mL	11.8627 mL	23.7254 mL	118.6268 mL
5 mM	0.4745 mL	2.3725 mL	4.7451 mL	23.7254 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

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