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EG01377 2HCl

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Purity:99.56%

ee:100%

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COA CSFC HNMR IC LCMS

EG01377 2HCl

Catalog No. T11154LCas No. 2749438-61-5

EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377 2HCl against NRP1-a1 and NRP1-b1.EG01377 exhibits anti-angiogenic, antimigratory and antitumor activities.

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Pack Size	Price	Availability
1 mg	$148	In Stock
5 mg	$372	In Stock
10 mg	$568	In Stock
25 mg	$915	In Stock
50 mg	$1,250	In Stock
100 mg	$1,680	In Stock
500 mg	$3,370	In Stock
1 mL x 10 mM (in DMSO)	$539	In Stock

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Product Introduction

Bioactivity

Description	EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377 2HCl against NRP1-a1 and NRP1-b1.EG01377 exhibits anti-angiogenic, antimigratory and antitumor activities.
In vitro	EG0 1377 2HCl (30 μM) effectively diminishes HUVEC cell migration induced by VEGFA. Additionally, EG01377 2HCl leads to reductions in network area, length, and branching points.[1] EG0 1377 2HCl (3-30 μM; 30 minutes) inhibits vascular endothelial growth factor A (VEGF-A) stimulated tyrosine phosphorylation of VEGF-R2/KDR with an IC50 of 30 μM.[1] EG0 1377 2HCl (30 μM; 5 days) can delay the VEGF-induced wound closure.[1] EG0 1377 2HCl diminishes VEGF-triggered angiogenesis. Moreover, when combined with VEGFA, EG01377 2HCl curtails spheroid outgrowth of A375P (malignant melanoma) cells.[1] EG0 1377 2HCl (500 nM; 2 h) blocks the production of transforming growth factor beta (TGFβ) by Nrp1+ regulatory T-cell SMAD3/AKT (Tregs) in the presence of tumor cell-derived factors.[1]
In vivo	EG0 1377 2HCl (2 mg/kg; i.v.; BABL/c female mice) possesses a half-life of 4.29 hours, allowing for once-a-day dosing to be maintained in mice.[1]
Alias	EG01377 2HCl(2227996-00-9 Free base)

Chemical Properties

Molecular Weight	659.6
Formula	C26H32Cl2N6O6S2
Cas No.	2749438-61-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 180.0 mg/mL (272.9 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5161 mL	7.5804 mL	15.1607 mL	75.8035 mL
5 mM	0.3032 mL	1.5161 mL	3.0321 mL	15.1607 mL
10 mM	0.1516 mL	0.7580 mL	1.5161 mL	7.5804 mL
20 mM	0.0758 mL	0.3790 mL	0.7580 mL	3.7902 mL
50 mM	0.0303 mL	0.1516 mL	0.3032 mL	1.5161 mL
100 mM	0.0152 mL	0.0758 mL	0.1516 mL	0.7580 mL

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