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Iptacopan hydrochloride
🥰Excellent
Catalog No. T9189Cas No. 1646321-63-2
Alias LNP023 hydrochloride, Iptacopan HCl
Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. Iptacopan hydrochloride shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM.
Iptacopan hydrochloride
🥰Excellent
Purity: 99.84%
Catalog No. T9189Alias LNP023 hydrochloride, Iptacopan HClCas No. 1646321-63-2
Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. Iptacopan hydrochloride shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $155 | In Stock | |
| 5 mg | $328 | In Stock | |
| 10 mg | $563 | In Stock | |
| 25 mg | $879 | In Stock | |
| 50 mg | $1,190 | In Stock | |
| 100 mg | $1,620 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $333 | In Stock |
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Purity:99.84%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. Iptacopan hydrochloride shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM. |
| Targets&IC50 | FB:10 nM, FB:7.9 nM(KD) |
| In vitro | LNP023 demonstrates excellent selectivity over other proteases affording IC50 values of >30 μM across a panel of 41 human proteases, including the AP protein factor D (>100 μM)[3]. |
| In vivo | LNP023 (20-180 mg/kg; oral administration) demonstrates efficacy in both prophylactic and therapeutic dosing in a rat model of membranous nephropathy and prevents KRN (150 μL)-induced arthritis in mice[2]. Following oral administration (rat 30 mg/kg, dog 10 mg/kg), LNP023 exhibits moderate half-lives (T1/2; Wistar Han rats 3.4 h, beagle dogs 5.5 h) and Cmax (Wistar Han rats 410 nM, beagle dogs 2200 nM)[3]. |
| Alias | LNP023 hydrochloride, Iptacopan HCl |
| Molecular Weight | 458.98 |
| Formula | C25H31ClN2O4 |
| Cas No. | 1646321-63-2 |
| Smiles | Cl.CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 50 mg/mL (108.94 mM), Sonication and heating are recommended. DMSO: 50 mg/mL (108.94 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
uremicsystemsyndromePNHpathwaypathogenesisparoxysmalnocturnalLNP-023 HydrochlorideLNP023 HydrochlorideLNP-023LNP023LNP 023 HydrochlorideLNP 023Iptacopan hydrochlorideIptacopan HydrochlorideIptacopanInhibitorinhibithemolytichemoglobinuriafactor BComplementSystemComplement Systemcomplementatypicalalternative
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